echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Immunology News > ​Nat Metab Huang Hai/Allan Tsung/Deng Meihong and others reveal the mechanism by which preoperative exercise induces Kupffer cell anti-inflammatory immunity after training to reduce liver damage

    ​Nat Metab Huang Hai/Allan Tsung/Deng Meihong and others reveal the mechanism by which preoperative exercise induces Kupffer cell anti-inflammatory immunity after training to reduce liver damage

    • Last Update: 2021-08-12
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com
    Zebian | Xi movement has been widely shown to maintain and restore the body, tissue homeostasis, cellular and molecular level, to prevent or inhibit a variety of diseases such as cancer, heart disease, hypertension, diabetes and the like
    .

    In clinical practice, a high level of physical reserve has been increasingly recognized as an indicator that is conducive to the prognosis of surgery.
    The concept of pre-rehabilitation training (Prehabilitation) is to systematically improve the cardiovascular reserve of patients before surgery.
    Ability to improve the systemic tolerance of systemic disorders that may exist during surgery
    .

    It has attracted more and more attention from medical institutions all over the world
    .

    However, the current research on preoperative exercise therapy to protect liver and other local organs from inflammation is still lacking, which hinders the wide application of this easy-to-use and economical non-drug treatment strategy
    .

    Understanding the underlying mechanism of preoperative exercise therapy will help to realize its full potential, and more importantly, help design potential pharmacological treatment targets for patients with exercise intolerance
    .

    On June 14, 2021, the research team of Huang Hai/Allan Tsung/Deng Meihong of Ohio State University published a research paper entitled Preoperative exercise therapy triggers anti-inflammatory trained immunity of Kupffer cells through metabolic reprogramming in Nature Metabolism.
    -cell RNA sequencing, scRNA-seq), mass spectrometry-based flow cytometry (CyTOF), SeahorseTM and Metabolomics and other technologies for liver macrophages, namely Kupffer cells (Kupffer Cells, KCs) before and after exercise liver ischemia-reperfusion injury A systematic study has been conducted on the role of KCs, and it is found that preoperative exercise can directly reduce the ischemia-reperfusion injury commonly seen in liver surgery, and that KCs play a key role in it [1]
    .

     The author of this article focuses on the inflammatory response and liver damage during liver surgery
    .

    Liver ischemia/reperfusion injury (I/R) injury is common in liver transplantation, partial hepatectomy, hemorrhagic shock, etc.
    It is an important reason for the success or failure of surgery and the death of patients
    .

    Existing treatment strategies have little effect in preventing liver I/R damage or significantly reversing liver I/R damage.
    Therefore, for patients undergoing liver surgery, especially patients with previous liver disease backgrounds such as liver function decline, it is especially necessary to change It is a reliable and effective treatment method
    .

    The author used a mouse liver I/R injury model to simulate I/R injury in clinical liver surgery, and found that 4 weeks of preoperative aerobic exercise can significantly protect the liver from inflammatory damage after liver I/R.
    This protective effect is in It still exists within 7 days after the completion of preoperative exercise therapy
    .

    The author further used single-cell RNA sequencing (scRNA-seq) and mass spectrometry-based flow cytometry (CyTOF) and other techniques to further research and found that exercise has an impact on the liver immune microenvironment
    .

    That is, the mouse liver macrophages involved in preoperative exercise, namely Kupffer cells, increased significantly, and the exercise group promoted the mouse liver Kupffer cells to have a significant anti-inflammatory phenotype
    .

    How does preoperative exercise prevent liver surgery complications [2] Exercise training has been shown to initiate the metabolic reprogramming of a variety of cells [3]
    .

    The metabolic status of immune cells is critical to their inflammatory phenotype.
    For example, pro-inflammatory macrophages obtain energy through aerobic glycolysis, while anti-inflammatory macrophages obtain energy through oxidative phosphorylation [4]
    .

    Based on this, the author used Seahorse and Metabolomics and other technologies to further analyze the liver KCs before and after exercise.
    The study found that exercise has an impact on the metabolic environment of liver KCs, that is, the way that preoperative exercise can make macrophages obtain energy is from pro-inflammatory ones.
    Oxyglycolysis is converted to oxidative phosphorylation that inhibits inflammation
    .

    Trained Immunity means that the innate immune system acquires immune memory, that is, when the innate immune cells experience long-term functional reprogramming when they encounter the first "stimulation" and then return to the inactive state, if they encounter the second "stimulation", It will be reactivated vigorously and exhibit a high degree of adaptive immunity [5]
    .

    The research mechanism found that exercise increases the level of Itaconate, which is an anti-inflammatory metabolite in the TCA cycle
    .

    Itaconate "trains" KCs into anti-inflammatory macrophages through the Nrf2 molecular signaling pathway, that is, exercise induces liver KCs to obtain anti-inflammatory trained immunity through metabolic reprogramming of Itaconate, and ultimately improves liver I/R.
    Inflammatory damage
    .

    Assistant Professor Huang Hai, Professor Allan Tsung, and Associate Professor Deng Meihong of the Department of Surgery of Ohio State University are the co-corresponding authors of the paper, and postdoctoral fellow Zhang Hongji is the first author of the paper
    .

    "Our research provides new ideas for the clinical response to surgical stress, and has also discovered the corresponding cellular and molecular targets, which can be used for potential drug development to simulate this preoperative exercise therapy strategy, so that patients with exercise intolerance can also benefit
    .

    "Yellow Sea assistant professor said," and hope that through our research is needed to urge everyone to adhere to exercise is beneficial to health again "
    .

    The laboratory is now recruiting 1-2 postdoctoral fellows and 1-2 visiting scholars
    .

    Original link: https:// Plate maker: 11 References 1.
    Zhang, H.
    , et al.
    Pre-operative exercise therapy triggers anti-inflammatory trained immunity of Kupffer cells through metabolic reprogramming.
    Nature Metabolism 3, 843-858 (2021).
    2.
    Heinz, A.
    & Hiller, K.
    Run to survive-how preoperative exercise could prevent major surgical complications.
    (2021).
    3.
    Koelwyn, GJ, Quail, DF, Zhang, X.
    , White, RM & Jones, LW Exercise-dependent regulation of the tumour microenvironment.
    Nature reviews.
    Cancer 17, 620-632 (2017).
    4.
    O'Neill, LAJ & Artyomov, MN Itaconate: the poster child of metabolic reprogramming in macrophage function.
    Nature Reviews Immunology 19, 273-281 (2019).
    5.
    Netea, MG, et al.
    Defining trained immunity and its role in health and disease.
    Nature Reviews Immunology 20, 375-388 (2020).
    Reprinting notice [Non-original article] The copyright of this article belongs to the author of the article.
    Personal forwarding and sharing are welcome.
    Reprinting is prohibited without permission.
    The author has all legal rights, and offenders must be investigated. .

    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.