Nat Neurosci: In Alzheimer's disease, PLC 2 mediates the inflammatory effects of small glial cells
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Last Update: 2020-07-14
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Source: Internet
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Author: User
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Human genetic data suggest that small glial dysfunction promotes the pathology of Alzheimer's disease (AD), for example, in TREM2, which is expressed in small glial cells, and in the phosphase-coding gene PLCG2Although studies in mouse models have involved specific Trem2-dependent small glial cell functions in AD, the potential molecular mechanisms and the convertability of human diseases are still unclearIn this study, researchers used genetically engineered human-induced pluripotentstem cellsderived from small glial cell sample cells found that TREM2 uses PLC-2 signals to mediate cell survival, swallowing power, processing of neuronal fragments, and lipid metabolismThe loss of TREM2 or PLC s2 signals leads to a common feature of transcription altimeas, which are the basis of these phenotypes, independent of TREM2, PLC 2 also signals downstream of toll-like receptors to mediate an inflammatory responsethus, the activity of PLC 2 regulates the function of different small glial cells through different TREM2-dependent and non-dependent signals, and may participate in the transformation of small glial cell states associated with neurodegenerative diseases
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