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According to the latest data released by the World Health Organization, esophageal cancer ranks eighth in the global cancer incidence and sixth in the mortality rate in the world, which seriously endangers human health
.
Surgery combined with radiotherapy and chemotherapy is a routine treatment for esophageal cancer.
However, resistance to radiotherapy and chemotherapy is still the main reason for clinical treatment failure
.
The generation of radiotherapy resistance is a complex process of multi-factor, multi-gene and multi-mechanism interaction, which is closely related to DNA damage repair, tumor hypoxia, tumor cell stemness, tumor metabolism and tumor microenvironment
.
Therefore, there is an urgent need to explore the liquid markers and potential therapeutic targets that predict the efficacy of radiotherapy, explore new strategies for overcoming the radiotherapy resistance of esophageal cancer, and provide new treatment models and strategies for achieving individualized and precise treatment
.
Researcher Chen Chunying of the National Nanoscience Center, researcher Liu Zhihua of the National Cancer Center/Tumor Hospital of the Chinese Academy of Medical Sciences and researcher Liu Huibiao of the Institute of Chemistry of the Chinese Academy of Sciences collaborated to design the graphyne-cerium oxide-miR181a nanosystem (Nano- miR181a)
.
Researchers used cell model screening and clinical sample analysis to find that miR181a can predict the efficacy of radiotherapy, and at the same time revealed that miR181a inhibits the expression of the target protein RAD17, promotes DNA damage-induced apoptosis, and achieves esophageal cancer radiotherapy sensitization
.
In order to further overcome the radiotherapy resistance of esophageal cancer, the researchers chose a new type of two-dimensional carbon material graphyne (GDY) as the carrier, and used the larger specific surface area of GDY to anchor the cerium oxide nanoparticles (CeO2 NPs) to reduce the aggregation of CeO2 NPs.
GDY-CeO2 nanocomposite with excellent catalase activity; Stabilize CeO2 NPs through the interaction between acetylene bonds and metal atoms, use charge transfer to promote catalytic reactions, and efficiently decompose endogenous H2O2 in the acidic tumor microenvironment Produce a large amount of O2, alleviate the hypoxia of tumor tissue
.
At the same time, as a high atomic number (Z) cerium element can enhance the deposition of radiation energy in cells, promote DNA damage, and enhance the efficacy of radiotherapy for esophageal cancer
.
In addition, the researchers used NH2-PEG-iRGD to modify GDY-CeO2, which not only improved the stability of miR181a and specifically bound to the ανβ3 integrin on the surface of tumor cells through the iRGD polypeptide, but also delivered miR81a to tumor tissues safely and efficiently
.
More importantly, in mouse subcutaneous xenograft models and human tumor xenograft models, it was confirmed that Nano-miR181a can achieve radiosensitization
.
In summary, this article explores that miR181a can be used as a liquid marker and new therapeutic target for predicting the efficacy of radiotherapy for esophageal cancer; Nano-miR181a uses nano-catalytic therapy, enhances intracellular radiation energy deposition, and miRNA drugs regulate multiple sensitization enhancements of the tumor microenvironment The efficacy of radiotherapy for esophageal cancer provides a new model for clinical treatment of esophageal cancer
.
Zhou Xuantong, a doctoral student at the Cancer Hospital of the Chinese Academy of Medical Sciences, and You Min, a postdoctoral fellow at the National Nanoscience Center, are the co-first authors of the paper
.
Researcher Chen Chunying from the National Nanoscience Center, researcher Liu Zhihua from the National Cancer Center/Tumor Hospital of the Chinese Academy of Medical Sciences, Deputy Chief Technician Luo Aiping, and researcher Liu Huibiao from the Institute of Chemistry of the Chinese Academy of Sciences are the co-corresponding authors of the paper
.
Paper information: Multifunctional Graphdiyne-Cerium Oxide Nanozymes Facilitate MicroRNA Delivery and Attenuate Tumor Hypoxia for Highly Efficient Radiotherapy of Esophageal CancerXuantong Zhou, Min You, Fuhui Wang, Zhenzhen Wang, Xingfa Gao, Chao Jing, Jiaming Liu, Mengyu Guo, Jiayang Li, Aiping Luo*, Huibiao Liu*, Zhihua Liu*, Chunying Chen*.
Advanced Materials DOI: 10.
1002/adma.
202100556 Click "Read the original text" in the lower left corner to view the original text of the paper
.
About Advanced Materials Journal "Advanced Materials" (Advanced Materials) is a well-known authoritative journal in materials science published by Wiley with a history of more than 30 years
.
The journal focuses on the frontier development of functional materials in various fields such as chemistry, physics, biology and related interdisciplinary subjects, and has a wide range of influence
.
The latest impact factor is 27.
389, and the 2020 SCI journals of the Chinese Academy of Sciences will be divided into the Q1 area of the material science category and the Q1 area of the engineering technology category
.
WILEYAdvancedScienceNewsWiley’s official WeChat platform for scientific research information long press the QR code to follow us to share cutting-edge information｜Focus on scientific research trends to publish scientific research news or apply for information sharing, please contact: ASNChina@Wiley.
com
.
Surgery combined with radiotherapy and chemotherapy is a routine treatment for esophageal cancer.
However, resistance to radiotherapy and chemotherapy is still the main reason for clinical treatment failure
.
The generation of radiotherapy resistance is a complex process of multi-factor, multi-gene and multi-mechanism interaction, which is closely related to DNA damage repair, tumor hypoxia, tumor cell stemness, tumor metabolism and tumor microenvironment
.
Therefore, there is an urgent need to explore the liquid markers and potential therapeutic targets that predict the efficacy of radiotherapy, explore new strategies for overcoming the radiotherapy resistance of esophageal cancer, and provide new treatment models and strategies for achieving individualized and precise treatment
.
Researcher Chen Chunying of the National Nanoscience Center, researcher Liu Zhihua of the National Cancer Center/Tumor Hospital of the Chinese Academy of Medical Sciences and researcher Liu Huibiao of the Institute of Chemistry of the Chinese Academy of Sciences collaborated to design the graphyne-cerium oxide-miR181a nanosystem (Nano- miR181a)
.
Researchers used cell model screening and clinical sample analysis to find that miR181a can predict the efficacy of radiotherapy, and at the same time revealed that miR181a inhibits the expression of the target protein RAD17, promotes DNA damage-induced apoptosis, and achieves esophageal cancer radiotherapy sensitization
.
In order to further overcome the radiotherapy resistance of esophageal cancer, the researchers chose a new type of two-dimensional carbon material graphyne (GDY) as the carrier, and used the larger specific surface area of GDY to anchor the cerium oxide nanoparticles (CeO2 NPs) to reduce the aggregation of CeO2 NPs.
GDY-CeO2 nanocomposite with excellent catalase activity; Stabilize CeO2 NPs through the interaction between acetylene bonds and metal atoms, use charge transfer to promote catalytic reactions, and efficiently decompose endogenous H2O2 in the acidic tumor microenvironment Produce a large amount of O2, alleviate the hypoxia of tumor tissue
.
At the same time, as a high atomic number (Z) cerium element can enhance the deposition of radiation energy in cells, promote DNA damage, and enhance the efficacy of radiotherapy for esophageal cancer
.
In addition, the researchers used NH2-PEG-iRGD to modify GDY-CeO2, which not only improved the stability of miR181a and specifically bound to the ανβ3 integrin on the surface of tumor cells through the iRGD polypeptide, but also delivered miR81a to tumor tissues safely and efficiently
.
More importantly, in mouse subcutaneous xenograft models and human tumor xenograft models, it was confirmed that Nano-miR181a can achieve radiosensitization
.
In summary, this article explores that miR181a can be used as a liquid marker and new therapeutic target for predicting the efficacy of radiotherapy for esophageal cancer; Nano-miR181a uses nano-catalytic therapy, enhances intracellular radiation energy deposition, and miRNA drugs regulate multiple sensitization enhancements of the tumor microenvironment The efficacy of radiotherapy for esophageal cancer provides a new model for clinical treatment of esophageal cancer
.
Zhou Xuantong, a doctoral student at the Cancer Hospital of the Chinese Academy of Medical Sciences, and You Min, a postdoctoral fellow at the National Nanoscience Center, are the co-first authors of the paper
.
Researcher Chen Chunying from the National Nanoscience Center, researcher Liu Zhihua from the National Cancer Center/Tumor Hospital of the Chinese Academy of Medical Sciences, Deputy Chief Technician Luo Aiping, and researcher Liu Huibiao from the Institute of Chemistry of the Chinese Academy of Sciences are the co-corresponding authors of the paper
.
Paper information: Multifunctional Graphdiyne-Cerium Oxide Nanozymes Facilitate MicroRNA Delivery and Attenuate Tumor Hypoxia for Highly Efficient Radiotherapy of Esophageal CancerXuantong Zhou, Min You, Fuhui Wang, Zhenzhen Wang, Xingfa Gao, Chao Jing, Jiaming Liu, Mengyu Guo, Jiayang Li, Aiping Luo*, Huibiao Liu*, Zhihua Liu*, Chunying Chen*.
Advanced Materials DOI: 10.
1002/adma.
202100556 Click "Read the original text" in the lower left corner to view the original text of the paper
.
About Advanced Materials Journal "Advanced Materials" (Advanced Materials) is a well-known authoritative journal in materials science published by Wiley with a history of more than 30 years
.
The journal focuses on the frontier development of functional materials in various fields such as chemistry, physics, biology and related interdisciplinary subjects, and has a wide range of influence
.
The latest impact factor is 27.
389, and the 2020 SCI journals of the Chinese Academy of Sciences will be divided into the Q1 area of the material science category and the Q1 area of the engineering technology category
.
WILEYAdvancedScienceNewsWiley’s official WeChat platform for scientific research information long press the QR code to follow us to share cutting-edge information｜Focus on scientific research trends to publish scientific research news or apply for information sharing, please contact: ASNChina@Wiley.
com
