National Science Review: Ni Xiuwu/Zhang Dingyu and others have discovered new pathological features in patients with neo-coronary pneumonia.

Due to the rapid increase in new cases, coronavirus disease (COVID-19) in 2019 quickly attracted global attention and the pathogen was identified as SARS-CoV-2.
(October 4), according to real-time statistics released by Johns Hopkins University, there have been more than 34.95 million confirmed cases of new coronary pneumonia worldwide, with 1.03 million deaths.
these figures are updated daily and are expected to increase further.
although clinical observations have supported the majority of patients with severe COVID-19 showing severe immune diseases, which can lead to damage to the lungs and multiple extra-pulmonary organs, the spleen and lymph nodes have not been fully studied.
September 30, 2020, Hua zhong university of science and technology, Air Force Military Medical University, Shanghai Jiaoxuan University and other multi-unit cooperation, Yu Xiuwu, Liu Liang, Zhang Dingyu, Dynastyfu and other common communications published online in the National Science Review entitled "Pathological changes in the lungs and lymph The study, which examined the lungs and lymphatic organs of 12 COVID-19 victims, assessed histopathological changes in the lungs, spleen and lymph nodes, immune cell markers, and inflammatory factor expression.
the study found that major changes in the lungs included diffuse alfule damage, interstitrin fibrosis, and excretive inflammation, characterized by a wide range of slurry and fibrin oozing fluids, macrophage immersion, and the large production of inflammatory factors (IL-6, IP-10, TNF alpha, and IL-1 beta).
spleen and lung lymph nodes contain lesions of tissue structure damage and immune cell disorders, including lymphocyte reduction and macrophage accumulation.
findings provide pathological evidence linking lung and lymphatic organ damage in severe COVID-19 patients to deadly systemic respiratory and immune dysfunction.
2019 coronavirus disease (COVID-19) quickly attracted global attention due to the rapid increase in new cases.
new coronavirus infection is believed to have been transmitted from animals, and pathogens have been identified as SARS-CoV-2.
until January 2020, it is suspected that the first infected patients were infected with the virus through human-to-human transmission.
since January 2020, the virus has spread rapidly to most of China and other countries.
the rapid increase in new cases, coronavirus disease (COVID-19) in 2019 quickly attracted global attention, with pathogens identified as SARS-CoV-2.
(October 4), according to real-time statistics released by Johns Hopkins University, there have been more than 34.95 million confirmed cases of new coronary pneumonia worldwide, with 1.03 million deaths.
these figures are updated daily and are expected to increase further.
Although COVID-19 is usually an acute self-limiting disease characterized by pneumonia, approximately 15% of COVID-19 patients (especially those with older and pre-existing conditions) can rapidly develop into fatal systemic diseases, such as acute respiratory distress syndrome and severe cardiovascular or kidney injury, with 5 to 6% of cases likely to develop critical conditions with high mortality rates.
, the virological, epidemiological and clinical characteristics of COVID-19 have been extensively studied and the clinical characteristics analyzed.
, pathological changes associated with COVID-19 have yet to be clarified.
A recent study of COVID-19 deaths, complete or minimally invasive, found that SARS-CoV-2 hijacked angiosin-converting enzyme 2 (ACE2) into target cells and caused severe pathological changes in the lungs and multiple extra-pulmonary organs/tissues.
although clinical observations have supported the majority of patients with severe COVID-19 showing severe immune diseases, which can lead to damage to the lungs and multiple extra-pulmonary organs, the spleen and lymph nodes have not been adequately studied.
in order to analyze the pathological changes of severe respiratory distress syndrome and immunodeficiency in patients with severe COVID-19, the study conducted systematic autopsies and comprehensive pathological analysis of COVID-19 patients in 12 deceased patients.
findings of the study provide new evidence for pathological changes associated with COVID-19 and suggest clinical methods for the disease.
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