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On April 6, 2020, Zhang Guangxian of Thomas Jefferson University in the United States and Professor Zhang Wei of Shaanxi Normal University collaborated on a research paper entitled A dual effect of ursolic to the treatment of the over-the-life over-the-and direct remyelination (https://doi.org/10.1073/pnas.2000208117)The study found that ursolic acid (UA), a natural trichomonium compound that is widely present in fruit peels such as apples and plums, and many Chinese herbal medicines, has the effect of promoting the repair of CNS myelin damagehttps://doi.org/10.1073/pnas.2000208117researchers conducted experiments using laboratory-grade sancetic acid monomersUsing eAE, a classic animal model of multiple sclerosis, they simulated clinical conditions such as inflammatory cell immersion, myelin deactivation, and sexual paralysis in human diseasesTreatment begins on the 60th day after the moldmaking (late stage of the disease), when the brain and spinal cord have developed an involuntary myelin damage that requires myelin regeneration and nerve repairEncouragingly, the clinical symptoms of the diseased mice on the 20th day of bear gallacid treatment began to ease, and the paralysed mice gradually regained their basic mobility, albeit somewhat weakIn order to rule out the efficacy of bear fruit acid is due to its anti-inflammatory effect on the indirect protection of myelin, the researchers also used a copper-induced toxic demyelinating model and an exogenous organ-type brain film culture system to confirm the positive effects of bear fruit acid on myelin repairThe researchers say that while this is not a cure, it would represent a significant improvement in the quality of life of patients if they had similar effects in the patientbear palaenic acid therapy can alleviate chronic EAE, promote myelin regeneration and reduce axial mutation and neuronal dendritic destruction
in addition, the researchers also explored the molecular mechanisms of bear palaeontine that act on cellsConsistent with previous reports, bear gallbladder inhibits the differentiation of Th17 cells, an immune cell with a unique inflammatory nature that plays a key role in chronic inflammation and autoimmune diseasesWhat's more, unlike immunomodulators that only act on Th17 cells, bear sancetic acid can also stimulate pre-myelin neurotrophic factors before astrocytes are produced, as well as regulate the expression of myelin to form related genes during the maturation of less protrusive glial cellsThis development altimeenist effect is very critical, because there are a large number of small progellin precursor cells (OPC) in MS patients, they are stuck in the "sleep" state can not be normal differentiation and maturation, is an important reason to inhibit myelin damage repairBeargine, which helps activate these cells and promotes their maturation at CNS to form myelin-forming fewer glial cells, may be a key cause of symptom reliefthe EAE immunomodulation and neuroregeneration models mediated by bear fruit acid
although the evidence from animal disease models is preliminary, it is encouraging to see in the laboratory a natural compound that can both stop and repair nerve damage from myelin disease The next step for researchers is to test the safety of the compound, and there are still many tests to be completed before the first clinical trial The clarification of the dual biological activity of bear fruit acid immunomodulation and myelin regeneration will lay the foundation for its clinical treatment of demyelinating diseases such as MS , it is reported that Zhang Wei and Dr Li Xing of Shaanxi Normal University are the co-authors of the paper, and Professor Abdolmo Hamad Rostami and Zhang Guangxian of Thomas Jefferson University in the United States are the authors of the newsletter references: a dual effect of ursolic sic acid to the endof the multiple-eras, a dheiletadandiar and direct remyelin
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Original title: PNAS: Natural small molecules in the peel can be used to treat myelin damage from multiple sclerosis