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Smoking can cause a variety of cancers, as well as diseases of the respiratory system and cardiovascular and cerebrovascular systems
.
According to WHO statistics, smoking causes approximately 7 million deaths each year
In China, the number of smokers exceeds 300 million, and it is also the world's largest producer and consumer of cigarettes, consuming 40% of the world's tobacco
.
In November 2021, Xu Ningzhi from the Cancer Hospital of the Chinese Academy of Medical Sciences and Jiang Jingmei from Peking Union Medical College and others published a study in the BMJ sub-Journal Tobacco Control, showing that the number of deaths from smoking-related cancers in China will increase by about 50% in the next two decades
.
Due to the many health hazards of smoking, many smokers want to quit or try to quit
.
But one of the difficulties of long-term withdrawal is weight gain (referring to smoking cessation-related weight gain, SCWG)
On December 8, 2021, researchers from the Weizmann Institute of Science in Israel published a research paper titled: Gut microbiota modulates weight gain in mice after discontinued smoke exposure in Nature
.
The study showed that changes in the intestinal flora after cessation of exposure to tobacco smoke may cause additional weight gain
.
This finding helps to improve the understanding of why people often gain weight after quitting smoking
The research team examined the intestinal flora of mice exposed to tobacco smoke for three weeks and compared it with unexposed mice
.
It turns out that exposure to smoke changes the intestinal flora, and further changes occur after the smoke exposure ceases (but it does not return to normal)
These changes in composition enhance intestinal energy intake and change the level of microbial metabolites.
As a result, body weight will increase even if calorie intake is restricted
.
Depletion of intestinal flora with antibiotics can prevent weight gain associated with smoking cessation, indicating that weight gain depends on the intestinal flora, and further experiments have shown that tobacco's non-nicotine components cause these effects
In addition, the study also observed similar changes in the composition and metabolites of the intestinal flora in a human group, but this preliminary experiment needs to be confirmed by a larger controlled study
The author believes that the mechanism of weight gain after smoking cessation and the intestinal flora may guide intervention to improve the success rate of smoking cessation, but larger trials are needed to confirm the relevance of this mechanism in human smokers
Original source:
Original source:Fluhr, L.
Gut microbiota modulates weight gain in mice after discontinued smoke exposure in this message
