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    Home > Biochemistry News > Biotechnology News > Nature answers long-term questions: Why is dieting so difficult, because neurons say "It makes me unhappy!"

    Nature answers long-term questions: Why is dieting so difficult, because neurons say "It makes me unhappy!"

    • Last Update: 2021-08-01
    • Source: Internet
    • Author: User
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    In the past ten years, researchers at the Beth Israel Deaconess Medical Center (BIDMC) have been hoping to find the small number of neurons deep in the brain that cause hunger, but so far, these cells and cells have caused unpleasant How exactly hunger drives animals to find and eat food is still unknown


    Now, this research group has finally found new clues for this long-standing problem


    Related results were published in Nature magazine


    "Our findings provide answers to this important question, namely, how do we learn to find and eat food, and how hunger enhances learning for food-oriented tasks," Lowell said.


    Researchers also found a small number of neurons in the hypothalamus of the brain: AgRP starvation neurons, which are responsible for hunger after a period of no food


    "Using this model, we soon discovered that these neurons can be turned on by fasting and hunger, and turning them on artificially in recently fed mice will trigger a large amount of food, as if they have not eaten for several days.


    In addition, the researchers analyzed that as long as the presence of food or cues related to the presence of food would immediately inhibit neuronal activity, thereby alleviating unpleasant hunger


    In the latest research, the team trains engineered mice to recognize food cues by associating light with access to food, just as dogs can be trained to associate the sound of a cupboard opening with the sound of obtaining a cookie


    As they expected, they observed that fasting activates AgRP neurons, while food cues in the environment can inhibit AgRP activity through neuronal networks elsewhere in the brain


    Based on this, researchers believe that fasting or inability to obtain food activates AgRP neurons and hunger, which can lead to unpleasant or disgusting feelings


    "It's as if these beneficial, unpleasant declines in AgRP neuron activity associated with sensory cues push mice toward environmental cues and tasks related to food," Lowell said, noting that thirst may arise in the same way.


    "An obvious implication of this idea is that it explains why dieting is so difficult: dieters are always troubled by this feeling of disgust


    (Biocom)

    Original link:

    http://dx.


    Food cue regulation of AGRP hunger neurons guides learning

     

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