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Nature BME: Long-term activation of innate immune pathways by multivalent STING agonists

 Last Update: 2021-03-19
 Source: Internet
 Author: User

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Interferon gene stimulating protein (STING) is an endoplasmic reticulum transmembrane protein, which is a target for the treatment of infectious diseases and cancer.

Tumor immunity

The researchers in this paper have previously synthesized a library of pH-sensitive polymers with linear or cyclic tertiary amine structures.

The degree of STING activation depends on the length of the polymer, which determines the valence state of the interaction.

In summary, this study emphasizes the use of synthetic polymers to induce STING condensation to activate natural immune pathways to exert anti-tumor effects .

The use of synthetic polymers to induce STING condensation to activate the innate immune pathway to exert anti-tumor effects.

Li, S.
, Luo, M.
, Wang, Z.
et al.
Prolonged activation of innate immune pathways by a polyvalent STING agonist.
Prolonged activation of innate immune pathways by a polyvalent STING agonist.
Nat Biomed Eng(2021).
https: //doi.
org/10.
1038/s41551-020-00675-9 leave a message here

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