echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > Nature Cancer: A new method to reverse tumor immunosuppression

    Nature Cancer: A new method to reverse tumor immunosuppression

    • Last Update: 2021-09-30
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com


    Image: Immunofluorescence image of lungs treated with radiation (left) or without radiation (right)


    Image courtesy of Dr.


    Malignant tumors can enhance their ability to survive and spread by suppressing nearby anti-tumor immune cells, but a study led by researchers at Weill Cornell School of Medicine and New York Presbyterian School of Medicine has discovered a new method To combat this immunosuppressive effect


    In the study published in the journal Nature Cancer on September 20, researchers discovered a group of anti-immunosuppressive factors that can be secreted by club cells located in the airways of the lungs


    Inhibition of MDSCs leads to an increase in the number of anti-tumor T cells at the tumor site, which greatly improves the effectiveness of FDA-approved PD1 immunotherapy


    "The factors secreted by these club cells can render the immunosuppressive cells ineffective, otherwise these cells would help tumors evade an effective anti-tumor response," said co-senior author Dr.


    This research is part of an extensive scientific effort in recent decades to find ways to use the immune system to fight cancer


    In this new study, Dr.


    Using a mouse model of non-small cell lung cancer, the most common lung cancer, they confirmed for the first time that this effect reached a moderate dose of radiation and caused a four-fold, 40%, proportion of survivors of ICI-treated mice suffering from tumors.


    The researchers later discovered that radiation achieves this effect by activating and stimulating the proliferation of club cells that reside in the lungs


    "We may see that at a specific radiation dose, these cells are stimulated at a peak, because the low dose does not stress the cells enough, and the high dose kills them," said Dr.


    The activated club cells secrete various molecules.


    They also determined that this immune restoration effect of club cell molecules stems from their suppression of mdscs, which has long been regarded as an obstacle to improving the efficacy of cancer immunotherapy


    In order to confirm the relevance of these laboratory findings to human cancer, researchers observed serum samples from lung cancer patients in a clinical trial of radiation therapy plus ICI.


    Researchers are now working to determine which molecules in the club cocktail are most important for suppressing MDSCs and enhancing cancer treatment


    "We hope that these secreted molecules can not only enhance the treatment of patients with non-small cell lung cancer, but also the treatment of other cancer patients," said Dr.
    Gao.
    "These molecules can also be used as biomarkers to predict the response of combined radiotherapy and immunotherapy
    .
    "



    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.