Nature Cancer: Wu Da Zhongbo team reports: Gouclusase USP25 may promote the occurrence of colorectal cancer

!---- existing studies have shown that bacterial infections or abnormal colonies in the gastrointestinal system are associated with some inflammatory bowel disease and colorectal cancerrecently, the Zhongbo team at Wuhan University found that ubiquitin-specific protease 25 (USP25) plays an important role in experimental colitis, bacterial infections and colon cancerAfterinduced experimental colitis or bacterial infection, USP25 knockout or drug suppression enhances the immune response, promotes the removal of infected bacteria and the suppression of inflammation, and weakens the transmission of Wnt and SOCS3-pSTAT3 signals, thus inhibiting the occurrence of colon tumorsUSP25 levels were positively correlated or negatively related to the levels of nucleic acid in human colorectal tumor biopsies and beta-catenin levels or SOCS3 levels, respectively, and predicted adverse prognosis in cancer patients with gastrointestinal systemstherefore, the results of the study show that USP25 is a target for gastrointestinal infections and cancer promoters and drugs