Nature Cell Biology: Golgi-derived vesicles regulate the division of endosomes

Associate researcher Jia Shunji of the School of Life Sciences published a paper revealing that Golgi-derived vesicles regulate the division of

On June 28, 2021, Associate Researcher Jia Shunji (Professor Anming Meng’s team) from the School of Life Sciences of Tsinghua University and the laboratory of Researcher Li Dong from the Institute of Biophysics of the Chinese Academy of Sciences published a titled "Golgi secretory vesicles by promoting phosphatidylinositol" on Nature Cell Biology.

In this study, the researchers used high-resolution imaging combined with electron microscopy to identify a vesicle derived from the Golgi apparatus and highly expressing SEC14L2, named SEC14L2 vesicle

At the same time, SEC14L2 vesicles promote the accumulation of PtdIns3P and the removal of PtdIns4P in the endosome before the endocytosis is divided

Through the capping experiment, the researchers found that in SEC14L2 knockout cells, the abnormal division of endosomes can be rescued by wild-type SEC14L2, but cannot be rescued by PtdIns3P binding-deficient SEC14L2 (SEC14L2-M5) It proved that the phosphatidylinositol binding ability of SEC14L2 is necessary for SEC14L2 vesicles to regulate the division of endosomes

Associate researcher Jia Shunji from the School of Life Sciences of Tsinghua University and researcher Li Dong from the Institute of Biophysics of the Chinese Academy of Sciences are the corresponding authors of the paper

The research was supported by the National Natural Science Foundation of China's Major Research Program (Fund No.

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