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Nature Chemical Biology: How Stressful Tumor Cells Escape Cell Death

 Last Update: 2022-10-02
 Source: Internet
 Author: User

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When free radicals get out of control and disrupt protective cell membranes in a chain reaction, cells die of iron death (Ferroptosis

It was only recently learned that human cells can produce so-called persulfides

Uladzimir Barayeu of DKFZ, the first author of the paper, observed that once cells are subjected to free radical stress, they increase the production of persulfides and are at risk of

The action of persulfides is based on an unusual chemical mechanism

Scientists at the University of Heidelberg have also shown that the sensitivity of cells to iron death depends on certain sulfur metabolic enzymes

Original:

Barayeu U, Schilling D, Eid M, Xavier da Silva TN, Schlicker L, Mitreska N, Zapp C, Gräter F, Miller AK,Kappl R, Schulze A, Friedmann Angeli JP, Dick TP (2022) Persulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals.

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