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    Home > Active Ingredient News > Endocrine System > Nature Communications: Drinking yogurt for just 3 months promotes metabolic health and reduces diabetes risk

    Nature Communications: Drinking yogurt for just 3 months promotes metabolic health and reduces diabetes risk

    • Last Update: 2022-04-20
    • Source: Internet
    • Author: User
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    Diabetes is a chronic disease that affects more than 460 million people worldwide
    .


    With changes in living and eating habits, diabetes has become the third largest factor affecting human health after cardiovascular and cerebrovascular diseases and malignant tumors


    Diabetes is a chronic disease that affects more than 460 million people worldwide

    It is well known that diet shapes the gut microbiome, which is an integral part of the human body, affecting weight, digestion, protection against infection and autoimmune disease risk, and even control of the body's response to drugs reaction,
    etc.

    Given the growing role of the gut microbiome in human health, many people are looking for ways to reliably and effectively improve their gut microbiome
    .

    On March 15, 2022, researchers from Laval University in Canada published an article entitled " Gut microbiota and fermentation-derived branched chain hydroxy acids mediate health benefits of yogurt consumption in obese mice " in the journal " Nature Communications ", a sub-journal of Nature.
    "Research Paper .

    Nature Communications Gut microbiota and fermentation-derived branched chain hydroxy acids mediate health benefits of yogurt consumption in obese mice

    The study shows that drinking yogurt for just 3 months promotes metabolic health and reduces diabetes risk, and uncovers the mechanism by which yogurt consumption reduces diabetes risk.


    thing


    In this study, the researchers fed mice a high-fat, high-sucrose diet to make the mice obese and analyzed the effect of yogurt on diet-induced obesity and related metabolic disorders
    .

    The researchers divided the mice into three groups that received post-diet yogurt treatment for 12 and 15 weeks, respectively, and measured the overall effects of yogurt treatment on body weight, liver metabolism, and indices of glucose homeostasis and insulin resistance
    .

    The third group was fed yogurt for 12 weeks and the effects of yogurt treatment on systemic, hepatic and peripheral insulin sensitivity were measured
    .


    Feeding the equivalent of two servings of yogurt per day replaced 7.


    The analysis found that after 12 weeks of yogurt treatment, mice fed a high-fat diet lost 2.
    9 percent of their body weight, reduced fasting blood sugar and insulin resistance, and effectively prevented liver steatosis
    .

    Drinking yogurt increases BCHA levels in mice

    Drinking yogurt increases BCHA levels in mice Drinking yogurt increases BCHA levels in mice

    Further, the researchers analyzed all metabolites present in the liver and observed changes in branched-chain hydroxy acids (BCHA), a metabolite produced in yogurt
    .

    The study found that the amount of these metabolites in the blood and liver decreased with weight gain in control mice that did not drink yogurt
    .


    In the yogurt group, some mice maintained BCHA content in their livers


    BCHA is a cell-autonomous regulator of liver and muscle glucose metabolism

    BCHA is a cell-autonomous regulator of liver and muscle glucose metabolism BCHA is a cell-autonomous regulator of liver and muscle glucose metabolism

    To explore the biological role of BCHA in the preventive effect of yogurt treatment on diabetes, the researchers correlated their abundance with relevant metabolic parameters
    .


    The study found that BCHA levels in the liver were negatively correlated with fasting blood glucose and hepatic triglyceride content


    Notably, diet-induced obesity reduced BCHA levels in plasma and tissues, implying that it could be prevented by dietary yogurt intake
    .

    Taken together, the findings suggest that just three months of yogurt intake partially prevents BCHA reduction in obese animals, promotes metabolic health throughout the day, reduces diabetes risk, and prevents hepatic steatosis in obese mice
    .


    It was revealed that yogurt improved the effect of insulin on glucose metabolism in liver and muscle cells by affecting the liver metabolome, especially maintaining the levels of branched-chain hydroxy acids associated with improved metabolic parameters


    Original source:

    Original source:

    Daniel, N.


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