Nature Communications: What's new! The rate of asymmetry in the left and right brains may indicate a risk of Alzheimer's disease

The brain is the most advanced part of the nervous system, consisting of the left and right hemispheres of the brain, which are connected by horizontal nerve fibers.
each hemisphere includes: the cerebral cortical layer (cerebral cortical): a layer of gray mass on the surface (the concentrated part of the cell body of nerve cells).
the surface of the human brain has a lot of recessed grooves (cracks), ditches (cracks) between the bulging back, thus greatly increasing the area of the cerebral cortical layer.
Of all animals, the human cerebral cortical layer is the most developed, is the organ of thought, dominates all the processes of activity in the body, and regulates the balance between the body and the surrounding environment, so the cerebral cortical layer is the material basis necessary for advanced neural activity, such as memory and other advanced cognitive functions.
study found that the thickness of the cortical layer in the left and right hemispheres of the brain is not the same, a phenomenon known as "cortical asymmetry", which is mainly related to slightly different functions of the left and right brain and is thought to help the brain perform its best function.
as we age and time, the cerebral cortical becomes thinner and the symmetry of the thickness of the cortical body changes, so the function of the brain decreases.
similar to aging, Alzheimer's disease (commonly known as Alzheimer's disease, AD) is associated with sexual damage to brain tissue.
, however, there is still a lack of information about the effects of brain structural asymmetric tissue networks on cognition and AD.
, experts from the Institute of Brain Function at the University of Oslo in Norway studied tissue symmetry in the brain's aging process.
results were published in the latest issue of Nature Communications, a sub-journal.
team is affiliated with Lifebrain, an international coalition of brain researchers.
researchers used large longitudinal data sets from five healthy elderly queues and one dementia queue to establish a thinning trajectory for healthy elderly cortical forces and to assess trajectory bias in Alzheimer's patients.
results included brain scans of more than 2,600 subjects, including AD, who measured the thickness of all areas of the subject's cerebral cortical layer and scanned the same subject up to six times during follow-up time to observe changes in the brain's structural regions over a lifetime.
results showed that participants showed significant asymmetries in the cerebral cortical regions around the age of 20.
in the process of aging, the thicker hemispheres at age 20 tend to thinn the cortical layer more quickly, showing diminishing asymmetry.
this variation shows a high degree of consistency in different queues, and the spatial patterns and time dynamics of asymmetric loss are significantly similar in validation queues.
further analysis showed that the thinnest areas of the cortique in healthy older adults tended to overlap with areas where AD patients showed more degeneration, indicating that the trajectory of thinning of the cerebral cortique in AD patients accelerated.
, the areas of the frontal and temporal lobes that are most significantly asymmetric during healthy aging tend to be more asymmetrical in AD patients.
, the study also found that throughout a person's life, the asymmetry of the cerebral cortical cortical is diminishing or even disappearing.
particularly in patients with AD.
, cortical asymmetry is expected to be a marker of early brain changes in AD before clinical cognitive symptoms of AD begin to appear.
: Roe JM, et al. Asymmetric thinning of the cerebral cortex across the adult lifespan is accelerated in Alzheimer's disease. Nat Commun. 2021 Feb 1; 12(1):721. doi: 10.1038/s41467-021-21057-y. MedSci Original Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mets Medicine" or "Source: MedSci Originals" are owned by Mets Medicine and are not authorized to be reproduced by any media, website or individual, and are authorized to be reproduced with the words "Source: Mets Medicine".
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