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    Home > Biochemistry News > Biotechnology News > Nature: Discover the most effective new coronavirus neutral antibodies.

    Nature: Discover the most effective new coronavirus neutral antibodies.

    • Last Update: 2020-10-01
    • Source: Internet
    • Author: User
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    These antibodies can be mass produced by pharmaceutical companies to treat patients, especially in the early stages of infection, and to prevent infection -- especially in the elderly.
    now have a range of more effective and diverse neutral antibodies than other previously discovered antibodies, and we are ready to develop them for treatment," he said.
    ," said Dr. David Ho, a professor of medicine at Columbia University's Wagos School of Internal Medicine and director of science at the Allen Diamond AIDS Research Center.
    researchers have confirmed that their purified strong-to-medium antibodies provide significant protection against SARS-CoV-2 infection in hamsters, and they plan to conduct further studies in other animals and humans.
    findings were published recently in the journal Nature.
    Photo Source: David Ho Columbia University Irving Medical Center Why do you look for a negative antibody One of the body's main responses to infection is to produce antibodies -- a protein that binds to an invading pathogen to mediate it and label it destroyed by immune system cells.
    that while some of the drugs and vaccines being developed for COVID-19 are in clinical trials, they may have to wait months to be ready.
    this time, SARS-CoV-2-2-medium antibodies produced by patients with COVID-19 can be used to treat other patients and even prevent infection in people exposed to the virus.
    of antibodies for treatment usually takes less time to develop and approve than traditional drugs.
    method is similar to recovery serum in patients with COVID-19, but may be more effective.
    The recovery serum contains a variety of antibodies, but because of the different immune responses of each patient, the antibody-rich plasma used to treat one patient may differ significantly from the plasma used to treat another patient, with different concentrations and strengths of the mesothesis antibody.
    patients with worsening conditions produce stronger antibodies When SARS-CoV-2 appeared at the beginning of the year and led to a pandemic, Ho quickly shifted the focus of his HIV/AIDS lab to studying the new virus.
    most of my team members have been working around the clock, 24 hours a day, 7 days a week since the beginning of March," says Ho.
    " researchers had easy access to blood samples from patients with moderate and severe illnesses treated at Columbia University Irvine Medical Center in New York City.
    City was at the center of the outbreak earlier this year.
    we have a lot of clinical material, which allows us to select the best cases to isolate these antibodies, " he said.
    " Ho's team found that although many patients infected with SARS-CoV-2 produce large numbers of antibodies, the quality of these antibodies varies.
    of the patients they studied, those with serious diseases that required mechanical aerity produced the most mesoth antibodies.
    believe that patients with more severe conditions are infected with the virus longer, making their immune systems more resilient," Ho said.
    " is similar to what we learned from the AIDS experience.
    anti-SARS-CoV-2 antibodies bind to the prickly glycoprotein on the surface of the virus, which is characteristic of the coronary structure of the virus.
    some of the most effective antibodies are directed to the binding region of the subject (the region where the virus binds to human cells), but others are directed to the N-side region of the prickly protein.
    the team has found more diverse antibodies than ever before, including new, unique antibodies that have not been reported before.
    these findings show which locations on the viral hedgehog protein are the most vulnerable, and the use of different antibody mixtures for different locations of the prickly protein will help prevent the virus from being resistant to treatment.
    effects on vaccines, " we found that it is not difficult for the immune system to produce these powerful antibodies.
    this bodes well for vaccine development.
    that produce strong neutral antibodies should provide strong protection against the virus.
    " Antibodies may be useful even when vaccines are available.
    , for example, vaccines may not work in older people, in which case antibodies may play a key role in protecting older people.
    photo source: David Ho Columbia University Irving Medical Center's Irving Medical Center Study shows that patients with severe illnesses are more likely to produce long-lasting antibody responses, but more research is needed to answer the key question of how long COVID-19 immunity will last.
    what to do next Researchers are currently designing experiments to test the strategy in other animals and eventually in humans.
    if the results of animal experiments also apply to humans, the pure, highly neutral antibody could be used in COVID-19 patients to help them remove the virus.
    the findings provide huge information for researchers developing vaccines and antiviral therapies, they are only early preclinical results, and these antibodies are not yet ready for use in humans.
    : Neutralizing antibodies isolated from COVID-19 patients may suppress virusLiu, L., Wang, P., Nair, M.S. et al. Potent neutralizing antibodies directed to multiple epitopes on SARS-CoV-2 spike. Nature (2020). DOI:10.1038/s41586-020-2571-7.
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