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    Home > Active Ingredient News > Antitumor Therapy > Nature: Engineered bacteria regulate tumor metabolism and promote immunotherapy effects

    Nature: Engineered bacteria regulate tumor metabolism and promote immunotherapy effects

    • Last Update: 2021-10-20
    • Source: Internet
    • Author: User
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    The availability of L-arginine in tumors is a key determinant of highly effective anti-tumor T cell responses
    .


    L-arginine in tumor cells is generally at a low concentration.


    Increasing the concentration of L-arginine in the tumor may greatly enhance the anti-tumor response of immune checkpoint inhibitors.


    Recently, researchers have studied whether L-arginine can have a synergistic effect with PD-L1 blockade
    .


    In mice with subcutaneous MC38 tumors, the researchers conducted tests and found that daily oral L-arginine and anti-PD-L1 treatment have a synergistic effect and increase the survival rate of the mice


    L-arginine and PD-L1 blocking therapies work synergistically to limit tumor growth in mice.


    L-Arg bacteria work synergistically with PD-L1 inhibitors to promote the rejection of MC38 tumors
    .

    L-Arg bacteria work synergistically with PD-L1 inhibitors to promote the rejection of MC38 tumors
    .


    L-Arg bacteria work synergistically with PD-L1 inhibitors to promote the rejection of MC38 tumors


    The strain can be colonized in tumors and continuously convert the metabolic waste products accumulated in tumors, ammonia, into L-arginine.


    In summary, these results indicate that engineered microbial therapy can metabolize the tumor microenvironment, thereby improving the efficacy of immunotherapy


     

    Original source:

    Original source:

    Fernando P.


    Fernando P.


     

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