Nature: Feng Guoping/ Fu Zhanyan/Li Yuqing, etc. to uncover the mystery of the chukes mesh core.

When you'!---- re focused on something, you tend to turn a deaf ear or turn a blind eye to everything around you.What physiological mechanisms does our brain rely on to achieve this function? The secret is hidden in the thalamic retinucleus, TRN.thalamus is the most important meta-change station for all sensory transmissions in the human brain except the sense of smell.various sensory conduction pathways are projected into the cerebral cortex after passing through the thalamus, where there is a nuclear cluster like a "gate" - the thysukal mesh nucleus. thethalamus mesh nucleus is located on the outside of the hypothalamus and has a "shell" form, consisting of a large number of gababutya (GABA) inhibitory neurons.it is thought to play a "gated" role in the transmission of information between the thysukal brain and the cortex, that is, like a gate to filter the sensory information, thereby regulating the body's sensory information processing, attention and sleep behavior, but because of the current knowledge of the basic tissue composition of the thalamus mesh nucleus, it is not possible to clarify its working mechanism.July 22, 2020, at the Stanley Center for Mental Illness at the Broad Institute, Joshua Levin, Fu Zhanyan, and Professor Feng Guoping of the Massachusetts Institute of Technology (MIT) collaborated with Professor Li Weiqing of Tsinghua University, Violeta G. Writing in the journal Nature, Professor Lopez Huerta and Broad Institute researcher Xian Adiconis, writing in the journal Nature, distinct subnetworks of the thalamic reti-nucleus, for the first time a comprehensive map of the thysukal mesh nucleus from the perspective of single-cell molecular properties, neuronal electrophysiological characteristics, local thysukal neural loopstructures, and functions.this new map further reveals the "mystery" of the thalamus mesh nucleus. To solve this critical problem, researchers from three laboratories with different experimental technical backgrounds and expertise conducted close collaborative research.they used a variety of cutting-edge techniques, including single-cell molecular properties, electrophysiological characteristics, neuronal network connectivity, CRISPR invivation, and systemic function, and found that the molecular heterogeneity of the hypothalamus-shaped nuclear neurons had very unique characteristics, showing a minus-related gene expression spectrum consisting of a numerical gradient (each expression lineage contains hundreds of genes).neurons located at both ends of the riomic gradient have very different physiological characteristics: the expression of mutually exclusive specially labeled proteins, spatially distributed in the core or edge region of the thysukal mesh nucleus, and has unique electrophysiological characteristics. What's more interestingis that in the loop structure they selectively separate the sensory and contact nuclei of the hypothalamus, forming a subnetwork, which functions differently in regulating sleep.Given the important role of hypothalamus mesh nuclear dysfunction in the onset of diseases such as autism, schizophrenia, dementia and epilepsy, this new map will greatly deepen scientists' understanding of the pathogenesis of diseases in which the thalamus mesh nucleus is involved, and lay a research foundation for the development of the thalamus nucleus as a new potential "effect target".noted that during the same period, Scott J. Cruikshank and Barry W. Brown university were among the Connors also published two articles about the two-year-old scareion driveion in the sensory thalamus, using The Cregmita mice of Calbindin (CP) and Somatostatin (SOM), and found two distinct TYPES of GABA energy neurons in the region of TRN sensory information regulation: they The former can be marked by CP and SOM, respectively; the former is in the middle of TRN, and the latter is mainly in the outer part of TRN; the former receives projections from the low-order thalamia group ventral posterior nucleus (VP), and the latter receives the posterior medial thalamic from the higher-order thalamus. Projection of nucleus (POM).more interesting, synapses from VP are fast and short, while synapses from POMs are slower and last longer.the study revealed the neural basis of the manipulation of the lower-order and high-order thalamus-cortex pathways by TRN in mice, showing the brain's distinct way of regulating the peripheral perception-cortex, cortex-cortex-interlayer information transmission through the thalamus. howlow-order and high-order information is integrated into the thalamus and its peripheral nuclear groups? How do different sensory information from body, hearing, vision, etc. interact with each other in these areas? How is the cortex involved in these regulatory and screening processes? Are there similar cellular mechanisms in primates? The study of these neurons will further explore these problems..