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One of the core ideas of acupuncture in the treatment of human diseases is that stimulation of specific areas of the body (acupoints) can regulate the physiological functions of the body at a distance.
This effect is believed to be achieved through hypothetical channels of meridians
.
Although modern anatomical research has not yet supported the actual existence of this channel, long-distance acupuncture and moxibustion can be achieved through somatosensory autonomic reflex
Acupuncture
In a recent study, researchers from the team of Professor Ma Qiufu of Harvard Medical School explored why electroacupuncture stimulation ( ES) can drive the recently reported vagus-adrenal axis from the Zusanli (ST36) point of the hind limb, and Instead of driving from the abdomen Tianshu (ST25) point, at Tianshu point, ES can drive the sympathetic reflex of the spine
.
Researchers have speculated that the somato-vagus-adrenal reflex is driven by sensory pathways that innervate the unique tissues of the hind limbs, such as joints, bones, and skeletal muscles
.
One candidate pathway includes DRG neurons labeled with PROKR2 Cre (where Cre-mediated recombination is used to label neurons with persistent or transient expression of prokineticin receptor 2)
The somatic-vagus-adrenal reflex is driven by the sensory pathways that innervate the unique tissues of the hind limbs, such as joints, bones and skeletal muscles.
Activation of PROKR2 ADV fibers drives the vagus nerve-adrenal gland anti-inflammatory axis
.
.
Activation of PROKR2 ADV fibers drives the vagus nerve-adrenal gland anti-inflammatory axis
PROKR2 Cre- labeled sensory neurons, which innervate the deep hindlimb fascia (such as periosteum) rather than the abdominal fascia (such as peritoneum), are essential for driving the vagus nerve-adrenal axis.
The optogenetic stimulation of PROKR2 Cre- labeled nerve endings through ST36 is sufficient to drive the vagus-adrenal axis instead of sympathetic reflex.
Original source:
Original source:Shenbin Liu et al.
Shenbin Liu et al.
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