echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Immunology News > Nature: Have you got a stomachache after eating? It could be a local allergy to the intestines...

    Nature: Have you got a stomachache after eating? It could be a local allergy to the intestines...

    • Last Update: 2021-03-03
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com
    Irritable bowel syndrome (IBS) is mainly manifested in abdominal pain and changes in intestinal activity, the signature symptoms of which are abnormal pain signals or visceral allergies (VHS).
    reported that as many as 20 percent of the world's people have gastrointestinal symptoms after a meal, and if this response can be intervened, the quality of life of this population can be greatly improved.
    mucous membrane immune system, which provides a balanced response to pathogens and harmless symblobacters, as well as food antigens, limiting unnecessary inflammation and the tissue damage it causes.
    , however, can interfere with dietary antigen tolerance, infectious gastroenteritis is an important risk factor for IBS.
    recently suggested that damage to oral food antigen tolerance caused by bacterial infections is the basis of food-induced VHS.
    recently, Nature magazine published online a study by Guy E. Boeckxstaens of the University of Leuven, Belgium, entitled "local immune response to food antigens drives meal-induced abdominal pain", suggesting that the local immune response of the intestines to food antigens causes abdominal pain after meals.
    in mice, oral tolerance to food antigens may decrease after infection with gut bacteria, which can lead to food-induced pain, similar to irritable bowel syndrome.
    researchers infected mice with BacillusC. Rodentium and then stimulated the mice's intestines with egg white protein (OVA) and found that mice showed only a local immune response, but no performance of a systemic immune response.
    further studies have shown that gastrointestinal bacterial infections can break oral tolerance to food antigens, leading to increased intestinal permeability and abnormal pain signals when exposed to antigens again.
    mechanisms of IBS infection in mice after OVA-stimulating bacterial infection may be associated with "low-level" inflammation and increased activation of fat cells.
    researchers found that locally produced OVA-specific antibodies in B cells and plasma cells sensitive fat cells and then mediated activation of fat cells when exposed to OVA again, contributing to the occurrence of VHS.
    the increase in visceral pain signals mediated by hypertrophic cells is mediated by histamine type 1 (H1R) and is related to the sensitivity of vanilla acid transient subsumption 1 (TRPV1), which is the channel through which histamines participate in regulating the body's many important physiological pathological functions, while TRPV1 is a channel protein widely distributed in the peripheral and central nervous systems.
    cells played a key role in the development of ova-induced VHS, the researchers injected soy, wheat, gluten and milk solutions into the colon mucous membranes of 12 IBS patients and 8 healthy volunteers.
    although the participants were not allergic to these dietary antigens, all participants in the IBS group developed mucous membrane reactions to at least one food antigen, while only two healthy volunteers showed a single positive reaction.
    further analysis showed that food antigens caused hypertrophobic cell activation in IBS patients and may have been mediated through IgE.
    , however, the fundamental difference with food allergies is that these participants only detected OVA-specific IgE antibodies in colon tissue, meaning that subjects showed only partial, not systemic, immune responses.
    the mucous membrane injection of food antigens can induce mucous membrane reactions in patients with irritable bowel syndrome in general, this study shows that IBS is a diet-induced disease mediated by the activation of fat cells.
    concept is important for the treatment of IBS and related diseases.
    Blocking hypertroller may be effective, and IgE-mediated hypertroller cell activation may also be a prognostic biomarker and therapeutic target for IBS patients, creating new possibilities for the treatment of irritable bowel syndrome and related abdominal pain disorders.
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Related Articles

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.