echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > Nature: How do active DNA molecules with therapeutic potential work

    Nature: How do active DNA molecules with therapeutic potential work

    • Last Update: 2022-01-07
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    DNAzymes-a word composed of DNA and enzymes-are DNA sequences with catalytic activity


    Its purpose is to target unwanted RNA molecules in viruses, cancers or damaged nerve cells, using DNAzymes to attack and destroy them


    The benefits of this therapy are obvious: unwanted RNA can be precisely destroyed, while other useful RNA strands in the cell remain intact


    Dr.


    In their research, authors from HHU and a team from the Jülich Research Center (FZJ), the University of Bonn, and a Swiss company tried to understand how the system as a whole works dynamically, and what steps take place in the process of combining and disintegrating.


    The researchers observed this process at atomic resolution and performed some real-time observations using a high-resolution nuclear magnetic resonance (NMR) spectrometer


    The team of Dr.


    Doctoral researcher Jan Borggrafe Etzkorn's working group and the first author of the study explained why DNAzymes do not work in cells: "We confirmed that magnesium, as an important cofactor, plays a variety of important mechanisms, but binds DNAzyme relatively poorly.


    The next step is to conduct structural studies on cell culture and organoids


    Dr.


    Journal Reference :

    1. Jan Borggräfe, Julian Victor, Hannah Rosenbach, Aldino Viegas, Christoph GW Gertzen, Christine Wuebben, Helena Kovacs, Mohanraj Gopalswamy, Detlev Riesner, Gerhard Steger, Olav Schiemann, Holger Gohlke, Ingrid Span, Manuel Eresolved Span, Time-resolved structural analysis.



    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.