echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Biochemistry News > Biotechnology News > "Nature" How do our organs know when to stop growing?

    "Nature" How do our organs know when to stop growing?

    • Last Update: 2022-01-10
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    The smallest fish in the world, Paedocypris, is only 7 mm long
    .


    This is nothing compared to the 9-meter-long whale shark


    Cells in developing tissues proliferate and organize under the action of signal molecules, namely morphogens
    .


    But how do they know that the size of the organism to which they belong is appropriate? The research team of Frank Jülicher, a professor in the Department of Biochemistry at the University’s Faculty of Science and director of MPIPKS in Dresden, solved the mystery by tracking a specific morphogen in tissue cells of different sizes in fruit flies


    In Drosophila, the morphogen pentapeptide (DPP) molecule required to form fifteen appendages (wings, antennae, jaw.


    .


    Multidisciplinary approach to solving biological problems

    "My team consists of biologists, biochemists, mathematicians, and physicists.


    The original method was to analyze what happened at the level of each cell, rather than placing our observations on the scale of tissues," Marcos Gonzalez Gaitan commented


    Explain the scaling mechanism with mathematical equations

    The scientists collected all these data on DPP, which came from cells belonging to different sizes of tissues in normal fruit flies and non-expandable mutants
    .


    They found that it is these different transportation steps that determine the extent of the gradient


    The combination of theoretical physics and experimental methods established through the study of DPP molecules in Drosophila can be extended to other molecules involved in the formation of various developmental tissues
    .


    "Our single and multidisciplinary approach allows us to provide a universal answer to a basic biological question that Aristotle had asked himself nearly 2500 years ago: how does an egg know when to stop growing to become a chicken? ?" Marcos Gonzalez-Gaitan concluded




    Magazine

    Nature

    DOI

    10.


    1038/s41586-021-04346-w

    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.