Nature: Immune cells actually secrete neurotransmitters to limit tumor immunity

Lymphocytes are regulated by the interaction of various receptors with soluble and cell-bound proteins
.

However, small metabolites from immune cells are also abundant in certain tissues, many of which may have signal potential that remains to be understood

Immune water-soluble metabolites can be used as environmental clues to mediate the interaction between immune cells.

Recently, researchers discovered that the metabolite and neurotransmitter GABA is a candidate signal molecule synthesized and secreted by activated B cells and plasma cells
.

Metabolite and neurotransmitter GABA is a candidate signal molecule synthesized and secreted by activated B cells and plasma cells Metabolite and neurotransmitter GABA is a candidate signal molecule synthesized and secreted by activated B cells and plasma cells

GABA is a major inhibitory neurotransmitter that regulates communication between neurons
.

Outside the brain, GABA has been detected in the intestines, spleen, liver, and pancreas

However, the cell source of GABA other than pancreatic β cells and neurons is still unknown
.

Although GABA precursors glutamine and glutamate are abundant in B cells and bone marrow cells, B cells are characterized by abundant GABA content, whether in resting (contralateral) or activated (ipsilateral) popliteal lymph nodes In

In addition, in non-targeted MS analysis of lymph nodes in mice or lymphocytes in human peripheral blood, GABA and other glutamate metabolism components are relatively more abundant in B cells
.

Analysis of the two converts glutamate to GABA in key enzymes that compared with T cells encoding glutamic acid decarboxylase 67 (GAD67) transcripts in mouse and human B cells are elevated , which This indicates that glutamate metabolism is characteristic of B-lineage cells in both species

GABA and other glutamate metabolism components are relatively more abundant in B cells GABA and other glutamate metabolism components are relatively more abundant in B cells The transcript encoding glutamate decarboxylase 67 (GAD67) is relatively abundant in mouse and human B cells are elevated encoding glutamic acid decarboxylase 67 (GAD67) transcripts in mouse and human B cells are elevated

B cells limit the anti-tumor response through GABA
.

B cells limit the anti-tumor response through GABA
.

B cells limit the anti-tumor response through GABA

B cell-derived GABA promotes monocytes to differentiate into anti-inflammatory macrophages, secretes interleukin-10, and inhibits the killing function of CD8+ T cells.

 

Original source:

Original source:

Baihao Zhang et al.

Baihao Zhang et al.

 

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