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▎WuXi AppTec's content team editors The long-term symptoms caused by the new crown infection have attracted continuous attention from the scientific community.
Physical discomfort such as fatigue, decreased mental status, and physical pain may exist six months or even a year after infection with the new crown, so it is also It's called "LONG COVID"
.
However, everyone still does not know the specific mechanism of the long-term new crown, so it is difficult to help the recovered patients who are deeply involved in it
.
Recently, a new study in "Nature-Immunology" found some immunological characteristics of long-term new crowns from a large number of recovered data, which may bring new insights for future new crown recovery and care
.
Basically, even people with mild symptoms had abnormal, long-lasting inflammatory responses eight months after infection, and the pattern of inflammation was different from other infections
.
Dr Chansavath Phetsouphanh, lead author of the study, said: "This is the first study of long-term Covid-19 from a laboratory analysis perspective, where the immune system is activated from infection and remains detectable months later
.
" During the pandemic, Australia's St Vincent's Hospital collected data on unvaccinated patients so that the impact of vaccines could be ruled out
.
The new study managed to obtain data on 62 patients diagnosed between April and July 2020, and analyzed patient samples at 3, 4 and 8 months of infection
.
Image source: 123RF In the study, they mainly tried to find changes in some protein markers in serum samples, involving a total of 31 different biomarkers that were judged to be related to the onset of the new crown, of which type I and type III interferon will be in the The rise continues early in the viral infection, which is the normal response of the immune system to infection
.
But after other infections are cleared, these immune markers disappear, but the new crown patients are completely different, and these markers persist in their bodies
.
"What we've found from long-term Covid-19 investigations is that the virus leaves the body without shutting down the immune system, but that's not the case at all in the cold patients in the control group,
"
explained Dr Phetsouphanh
.
▲Many inflammatory markers in new crown patients are abnormal after 8 months of infection (Image source: Reference [2]) In addition, the innate immune cells of new crown patients will be highly activated, but lack of initial T cells and B cells
.
And some inflammatory regulatory molecules, type I and type III interferon and interleukin-6, will form a specific combination in the patient's body
.
These changes may be related to initial lung epithelial cell damage, and in experiments in mice, dendritic cells in the lungs of mice produce large amounts of interferon in response to the virus
.
The researchers pointed out that when studies looked at new crown patients, they found that they were more difficult to predict the health recovery status of new crown patients
.
"The pathology and physiology of this disease are very unique," said Professor Gail Matthews, who was also involved in the study
.
The research team is currently analyzing some post-pandemic data of the Delta variant, and they want to determine whether vaccination can improve the negative immune profile of long-term Covid-19
.
Reference: [1] What causes long COVID symptoms? Cluesfrom under the microscope.
Retrieved Jan 17th, 2022 from https://medicalxpress.
com/news/2022-01-covid-symptoms-clues-microscope.
html[2] Chansavath Phetsouphanh et al, Immunological dysfunction persists for 8 months following initialmild-to-moderate SARS-CoV-2 infection, Nature Immunology (2022).
DOI: 10.
1038/s41590-021-01113-x
Physical discomfort such as fatigue, decreased mental status, and physical pain may exist six months or even a year after infection with the new crown, so it is also It's called "LONG COVID"
.
However, everyone still does not know the specific mechanism of the long-term new crown, so it is difficult to help the recovered patients who are deeply involved in it
.
Recently, a new study in "Nature-Immunology" found some immunological characteristics of long-term new crowns from a large number of recovered data, which may bring new insights for future new crown recovery and care
.
Basically, even people with mild symptoms had abnormal, long-lasting inflammatory responses eight months after infection, and the pattern of inflammation was different from other infections
.
Dr Chansavath Phetsouphanh, lead author of the study, said: "This is the first study of long-term Covid-19 from a laboratory analysis perspective, where the immune system is activated from infection and remains detectable months later
.
" During the pandemic, Australia's St Vincent's Hospital collected data on unvaccinated patients so that the impact of vaccines could be ruled out
.
The new study managed to obtain data on 62 patients diagnosed between April and July 2020, and analyzed patient samples at 3, 4 and 8 months of infection
.
Image source: 123RF In the study, they mainly tried to find changes in some protein markers in serum samples, involving a total of 31 different biomarkers that were judged to be related to the onset of the new crown, of which type I and type III interferon will be in the The rise continues early in the viral infection, which is the normal response of the immune system to infection
.
But after other infections are cleared, these immune markers disappear, but the new crown patients are completely different, and these markers persist in their bodies
.
"What we've found from long-term Covid-19 investigations is that the virus leaves the body without shutting down the immune system, but that's not the case at all in the cold patients in the control group,
"
explained Dr Phetsouphanh
.
▲Many inflammatory markers in new crown patients are abnormal after 8 months of infection (Image source: Reference [2]) In addition, the innate immune cells of new crown patients will be highly activated, but lack of initial T cells and B cells
.
And some inflammatory regulatory molecules, type I and type III interferon and interleukin-6, will form a specific combination in the patient's body
.
These changes may be related to initial lung epithelial cell damage, and in experiments in mice, dendritic cells in the lungs of mice produce large amounts of interferon in response to the virus
.
The researchers pointed out that when studies looked at new crown patients, they found that they were more difficult to predict the health recovery status of new crown patients
.
"The pathology and physiology of this disease are very unique," said Professor Gail Matthews, who was also involved in the study
.
The research team is currently analyzing some post-pandemic data of the Delta variant, and they want to determine whether vaccination can improve the negative immune profile of long-term Covid-19
.
Reference: [1] What causes long COVID symptoms? Cluesfrom under the microscope.
Retrieved Jan 17th, 2022 from https://medicalxpress.
com/news/2022-01-covid-symptoms-clues-microscope.
html[2] Chansavath Phetsouphanh et al, Immunological dysfunction persists for 8 months following initialmild-to-moderate SARS-CoV-2 infection, Nature Immunology (2022).
DOI: 10.
1038/s41590-021-01113-x
