Nature Immunology: The human immune system is an "early riser"

The circadian clock is one of the most basic biological mechanisms.

Research suggests that when vaccinating cancer vaccines or immunotherapy, time should be considered to improve their effectiveness

In order to understand the role of circadian rhythm in immune activation, the researchers observed the migration of dendritic cells from the skin to the lymphatic system, which is one of the pillars of the adaptive immune response

Synchronized clock

The scientists first observed the migration ability of dendritic cells in wild mice, four times a day, and then in mice without a normal biological clock

The researchers then repeated their experiments on human skin cells taken from patients at different times of the day

Stimulate the immune system at the right time

The additional data also shows that if the immune system is stimulated at different times of the day, the same oscillations will also occur, with the peak in the morning

Similarly, are we more susceptible to pathogens at night? It cannot be said yet

DOI

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Article title

Circadian clocks guide dendritic cells into skin lymphatics