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Nature Immunology: Weiping Zou's team from the University of Michigan reveals a new mechanism of MDM2-p53 inhibitor tumor immunology

 Last Update: 2021-04-13
 Source: Internet
 Author: User

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On March 26, the internationally renowned journal "Nature Immunology" published an online article "The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity" by Dr.

APG-115 is a new drug under development under Yasheng Pharmaceutical (6855.

In order to further explore the mechanism of the MDM2-p53 signaling pathway in T cells, the researchers constructed a mouse model that specifically knocked out MDM2 and p53 in T cells.

Before the start of this study, it is still unknown whether MDM2-p53 will affect the anti-tumor immune response mediated by CD8+ T cells.

Dr.

It is reported that Yasheng Pharmaceutical is currently carrying out a phase II clinical trial of APG-115 combined with pembrolizumab to treat patients with tumors that have developed drug resistance or recurrence after PD-1 inhibitor treatment.

Original source:

Zhou, J.

biodiscover.
com/news/industry/737875.
html" target="_blank" rel="noopener">The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated antitumor immunity.
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