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    Home > Active Ingredient News > Digestive System Information > Nature: Intestinal microbes affect B cells and antibody libraries.

    Nature: Intestinal microbes affect B cells and antibody libraries.

    • Last Update: 2020-08-22
    • Source: Internet
    • Author: User
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    B cells are white blood cells that produce antibodies.
    these antibodies or immunoglobulins can bind to harmful foreign particles, such as viruses or disease-causing bacteria, to prevent them from invading and infecting human cells.
    each B cell carries a separate B-cell receptor (BCR), which determines which particles it can bind to, just as each lock accepts a different key.
    millions of B-cells in the human body, which have different receptors.
    this huge diversity comes from the rearrangement of the genes encoded on these receptors, so the receptors in each B cell are slightly different, resulting in billions of different potentially identifiable harmful molecules.
    microbes triggered the expansion of these B-cell populations and the production of antibodies, but until now it was not known whether this was a random process or whether the gut microbes themselves influenced the results.
    a study published in the journal Nature, researchers analyzed the responses of billions of genes that encode antibodies into individual benign gut microbes in a system.
    the title of this article is "Mucosal or systemic microbiota exposures shape the B cells repertoire".
    of effective antibodies depends on where beneficial microorganisms are located in the body And the number of benign microorganisms in our guts is approximately the same as the number of cells in our bodies.
    that these bacteria mostly stay in the intestines, rather than penetrate into human tissues.
    , some penetration is inevitable because the intestine has only one layer of cells that separate the blood vessels and tubes we need to absorb food.
    researchers used specially designed computer programs to process millions of gene sequences that compare antibody pools from B cells, depending on whether the microbes remain in the gut or enter the bloodstream.
    both cases, the antibody library changes, but in a different way, depending on how the exposure occurs.
    different types of antibodies in the intestinal wall (IgA) than antibodies in the blood (IgM and IgG).
    powerful genetic analysis, the researchers found that the intestinal tract produced different antibodies that ranged far less than 100 antibodies produced by the body's central tissue.
    means that once microbes enter the body, the immune system has more chance to middle and destroy them, and the antibodies in the gut are mainly binding to bacterial molecules that can be seen at all times.
    how antibodies change through the life of mammals when the human body is exposed to different microorganisms, they face a variety of microbial challenges.
    therefore, it is important to know how the antibody bank will change once certain other microorganisms appear and once they are stereotyped by a particular microorganism.
    team answered this question by testing what happens to the same microorganism in different places or what happens to two different microorganisms in another location.
    although gut microbes do not directly produce a particularly wide range of different antibodies, if microorganisms enter the bloodstream, they make the central immune tissue sensitive, resulting in antibodies.
    when a second microbe appears, a fairly limited response to gut antibodies changes to suit the microbe (just like changing the door lock).
    This is not the case when the second group of antibodies produces a second group of antibodies without impairing the first reaction to the original microorganism (e.g. by installing another lock, so the door can be opened with a different key).
    suggests that central tissue has the ability to remember many different microbial species and avoid the risk of sepsis.
    also suggests that the use of different B-cell immune strategies in different locations is important to maintain our peaceful survival with microorganisms.
    : "1" (2) Source: Translational Medicine Network !-- end of the content display -- !-- determine whether the login ends.
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