"Nature" is heavy!

The role of skeletal stem cells (SSC) is to differentiate to produce bone cells and chondrocytes, and to provide a suitable microenvironment for the development of haematopoietic stem and progenitor cells (HSPC)

Recently, researchers such as Charles KF Chan and Michael T.

Difficulty in healing after a fracture is a major cause of the increase in mortality among the elderly.

Further research found that part of the problem of fracture healing may lie in the connection between skeletal stem cells and HSPC, and aging skeletal stem cells will produce a microenvironment that changes the development of blood cells

Chronic inflammation is closely related to the aging of many tissues and organs

In single-cell genetic analysis of aging bone stem cells, the researchers discovered a special factor called colony-stimulating factor 1 (Csf1)

In addition, the researchers also found that a skeletal stem cell called bone morphogenetic protein 2 (BMP2) stimulates the production of signal molecules.

By fighting the aging of skeletal stem cells, the researchers succeeded in making the fracture healing of old mice close to that of young mice

Reference materials:

[1]Aged skeletal stem cells generate an inflammatory degenerative niche