NATURE: IspH inhibitors are a two-pronged effort to kill Terrain-negative bacteria

Isoprene compounds are essential for all organisms, maintaining the stability of the membrane in the body and supporting core functions such as respiratory function.
IspH is an enzyme in the isoephedrine synthesis pathway of erythromylitol phosphate, which is essential for Terrain-negative bacteria, mold and conifers.
its substrate, (E)-4-hydroxyl-3-methyl-butine-2-ene coking phosphoric acid (HMBPP), which cannot be produced in later life.
in humans and other primates, the substrate activates cytotoxic V-9V-2 T cells at very low concentrations.
recently, researchers written in Nature describing a class of IspH inhibitors and designing them with structurally guided analogo designs to raise their potency to the namor level.
Researchers found that modifying these compounds to deliver the original drugs to bacteria can kill several clinically isolated drug-resistant bacteria, including Bacillus monocytobacteria, prosthetic monocytobacteria, Crebb, E. coli, Vibrio, Chic, salmonella, Yersinia, Mycobacterium and Bacillus aureus.
addition, the original drug is non-toxic to mammalian cells.
proteomics analysis showed that the bacteria treated with these original drugs were similar to those treated after the conditional IspH knock-out.
it is worth noting that these primary drugs can also induce the expansion and activation of human-induced mouse models of bacterial infections in human-called cells of V-9V-2 T.
, these IspH inhibitors can directly kill bacteria while activating the rapid immune response of cytotoxic gamma T cells, which may limit the increase in the population of antibiotic-resistant bacteria.
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