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    Home > Active Ingredient News > Antitumor Therapy > Nature: it is found that E-cadherin is an essential protein for the metastasis of breast cancer!

    Nature: it is found that E-cadherin is an essential protein for the metastasis of breast cancer!

    • Last Update: 2019-09-10
    • Source: Internet
    • Author: User
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    September 10, 2019 / BIOON / - metastasis is the main cause of cancer death According to the negative correlation between in vitro migration and E-cadherin level, it has been suggested that the invasion and metastasis of surrounding tissues begin after the loss of E-cadherin However, this hypothesis is inconsistent with the observation that most breast cancers are invasive ductal carcinoma and express E-cadherin in primary tumor and metastasis In order to solve this problem, researchers from Johns Hopkins University (JHU) and other units in the United States, led by Andrew J Ewald of JHU Medical College, tested the genetic needs of E-cadherin in the process of metastasis by using mice and human models of lumen cancer and basal invasive ductal cancer The relevant research results were recently published in nature, entitled "E-cadherin is required for metastasis in multiple models of breast cancer"。 Photo source: in their study, nature found that E-cadherin promotes metastasis in a variety of invasive ductal cancer models The loss of E-cadherin not only increases the invasion, but also reduces the proliferation and survival of cancer cells, the number of circulating tumor cells, the spread of cancer cells in distant organs and the growth of metastasis The researchers found that at the transcription level, E-cadherin was associated with up regulation of genes involved in transforming growth factor - β (TGF β), reactive oxygen species, and apoptosis signaling pathways At the cellular level, the E-cadherin negative cells showed Smad2 / 3 nuclear enrichment, oxidative stress and increased apoptosis Inhibition of TGF β receptor signaling, ROS enrichment or apoptosis can reverse the colony formation of E-cadherin negative cells The results show that E-cadherin plays a role of survival factor in the process of metastasis detachment, systemic diffusion and seeding of invasive ductal carcinoma by inhibiting apoptosis mediated by reactive oxygen species To determine the molecular strategy to inhibit the survival of E-cadherin-mediated metastatic breast cancer cells may have the potential to treat breast cancer Reference: Andrew J Ewald et al E-cadherin is required for metadata in multiple models of breast cancer Nature DOI https://doi.org/10.1038/s41586-019-1526-3
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