[Nature] Latest research: Vinblastine, an anti-cancer drug brewed from reprogramming yeast

This article is the original of translational medicine network, please indicate the source when reprinting

Author: Sophia

In the summer and fall of 2019, some cancer patients experienced a disruption in

An interdisciplinary international team of scientists led by DTU researchers genetically engineered yeast to produce vinblastine and Catherine

background

 01 

In the past few years, there have been several incidents of related cancer drug shortages in the market

The study may yield new sources of vindolines, catharanthines and other alkaloids that are completely independent of the factors that influence crop cultivation, such as plant diseases and natural disasters

A possible new supply chain of anticancer drugs

 02 

Vinblastine belongs to the so-called monoterpenesindole alkaloids (MIAs), which have strong biological activity and can be used to treat various diseases

Researcher Jie Zhang said: "To prove the feasibility of microbial manufacturing of all MIA, we chose one

The 31-step vinblastine research process was complex and, fortunately, succeeded

Research progress and results

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The team performed 56 gene edits to program 31-step biosynthetic pathways into baker's

The study further highlights recent advances in synthetic biology, in which engineered yeast is used in drug production

Jay D.

Resources:

https://phys.

This article is intended to introduce the progress of medical research and cannot be used as a reference for

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