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As of now, there is no widely available specific antiviral therapy for human coronaviruses.
Remdesivir (remdesivir) showed pan-coronavirus suppression potential and was approved by the FDA for the treatment of COVID-19 on the basis of shortening the recovery time.
However, this therapy is not ideal, especially for severely ill patients with COVID-19.
On March 16, local time, the top international academic journal "Nature" published online publications in the form of "Accelerated Article Preview" (Accelerated Article Preview) of the University of Hong Kong, the Sandford Burnham Plibris Medical Institute, etc A study by the team, entitled "Clofazimine broadly inhibits coronaviruses including SARS-CoV-2".
Studies have found that clofamizine, the drug currently used to treat leprosy, is effective against SARS-CoV-2 infection in human cells and hamster models.
The research team believes that aminophenazine can be taken orally and the manufacturing cost is relatively low.
These characteristics make it a potentially attractive drug candidate for the new crown.
Famphenazine can broadly inhibit human pathogenic coronaviruses in human cell models.
Fenazine is a drug approved by the US FDA for marketing.
The research team found that phenazine can reduce the replication of two coronaviruses (new coronavirus SARS-CoV-2 and Middle East respiratory syndrome coronavirus MERS-CoV) in human and monkey cell lines and human lung tissue.
Fenazine interferes with multiple steps in viral replication.
In the analysis of the drug's antiviral effects, the research team observed that the drug targets multiple steps in the replication of the new coronavirus, including interference with the cell fusion process and the activity of viral helicase.
Studies have concluded that in the hamster model of new coronavirus infection, the use of amphenazine before or after virus exposure can significantly reduce the number of virus particles found in the lungs.
It is worth noting that when combined with Redecivir, the two drugs have a synergistic effect in reducing virus replication.
Famphenazine prevents and treats COVID-19 disease.
The research team believes that low-dose remdesivir combined with aminophenazine can limit the improvement of the virus control effect in the hamster model.
They pointed out that aminophenazine may become an attractive drug candidate for outpatient treatment of the new crown.
More clinical studies are now needed to determine whether it has the potential to become an alternative therapy.
Link to the paper: Hot Article Selection in 2020 1.
The cup is ready! A full paper cup of hot coffee, full of plastic particles.
.
.
2.
Scientists from the United States, Britain and Australia “Natural Medicine” further prove that the new coronavirus is a natural evolution product, or has two origins.
.
.
3.
NEJM: Intermittent fasting is right The impact of health, aging and disease 4.
Heal insomnia within one year! The study found that: to improve sleep, you may only need a heavy blanket.
5.
New Harvard study: Only 12 minutes of vigorous exercise can bring huge metabolic benefits to health.
6.
The first human intervention experiment: in nature.
"Feeling and rolling" for 28 days is enough to improve immunity.
7.
Junk food is "real rubbish"! It takes away telomere length and makes people grow old faster! 8.
Cell puzzle: you can really die if you don't sleep! But the lethal changes do not occur in the brain, but in the intestines.
.
.
9.
The super large-scale study of "Nature Communications": The level of iron in the blood is the key to health and aging! 10.
Unbelievable! Scientists reversed the "permanent" brain damage in animals overnight, and restored the old brain to a young state.
.
.
Remdesivir (remdesivir) showed pan-coronavirus suppression potential and was approved by the FDA for the treatment of COVID-19 on the basis of shortening the recovery time.
However, this therapy is not ideal, especially for severely ill patients with COVID-19.
On March 16, local time, the top international academic journal "Nature" published online publications in the form of "Accelerated Article Preview" (Accelerated Article Preview) of the University of Hong Kong, the Sandford Burnham Plibris Medical Institute, etc A study by the team, entitled "Clofazimine broadly inhibits coronaviruses including SARS-CoV-2".
Studies have found that clofamizine, the drug currently used to treat leprosy, is effective against SARS-CoV-2 infection in human cells and hamster models.
The research team believes that aminophenazine can be taken orally and the manufacturing cost is relatively low.
These characteristics make it a potentially attractive drug candidate for the new crown.
Famphenazine can broadly inhibit human pathogenic coronaviruses in human cell models.
Fenazine is a drug approved by the US FDA for marketing.
The research team found that phenazine can reduce the replication of two coronaviruses (new coronavirus SARS-CoV-2 and Middle East respiratory syndrome coronavirus MERS-CoV) in human and monkey cell lines and human lung tissue.
Fenazine interferes with multiple steps in viral replication.
In the analysis of the drug's antiviral effects, the research team observed that the drug targets multiple steps in the replication of the new coronavirus, including interference with the cell fusion process and the activity of viral helicase.
Studies have concluded that in the hamster model of new coronavirus infection, the use of amphenazine before or after virus exposure can significantly reduce the number of virus particles found in the lungs.
It is worth noting that when combined with Redecivir, the two drugs have a synergistic effect in reducing virus replication.
Famphenazine prevents and treats COVID-19 disease.
The research team believes that low-dose remdesivir combined with aminophenazine can limit the improvement of the virus control effect in the hamster model.
They pointed out that aminophenazine may become an attractive drug candidate for outpatient treatment of the new crown.
More clinical studies are now needed to determine whether it has the potential to become an alternative therapy.
Link to the paper: Hot Article Selection in 2020 1.
The cup is ready! A full paper cup of hot coffee, full of plastic particles.
.
.
2.
Scientists from the United States, Britain and Australia “Natural Medicine” further prove that the new coronavirus is a natural evolution product, or has two origins.
.
.
3.
NEJM: Intermittent fasting is right The impact of health, aging and disease 4.
Heal insomnia within one year! The study found that: to improve sleep, you may only need a heavy blanket.
5.
New Harvard study: Only 12 minutes of vigorous exercise can bring huge metabolic benefits to health.
6.
The first human intervention experiment: in nature.
"Feeling and rolling" for 28 days is enough to improve immunity.
7.
Junk food is "real rubbish"! It takes away telomere length and makes people grow old faster! 8.
Cell puzzle: you can really die if you don't sleep! But the lethal changes do not occur in the brain, but in the intestines.
.
.
9.
The super large-scale study of "Nature Communications": The level of iron in the blood is the key to health and aging! 10.
Unbelievable! Scientists reversed the "permanent" brain damage in animals overnight, and restored the old brain to a young state.
.
.
