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    Home > Biochemistry News > Biotechnology News > Nature-Medicine: HIV virus suppression rate doubles AIDS CAR-T therapy is coming?

    Nature-Medicine: HIV virus suppression rate doubles AIDS CAR-T therapy is coming?

    • Last Update: 2020-09-19
    • Source: Internet
    • Author: User
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    In recent years, CAR-T cells have provided powerful tools for treating cancer.
    this therapy allows T cells to identify specific cells and remove them by transforming the patient's own immune T cells to express chime antigens (CAR).
    in addition to targeting cancer cells, designing different CAR can also allow T cells to identify and remove other types of diseased cells.
    study, scientists designed a new CAR-T cell that specifically targets HIV-infected cells.
    because the main target of HIV infection is T cells, so this CAR-T cell in addition to being able to survive and multiply in the body, it also needs to be able to resist HIV infection.
    the Immune T cells that express CD4 (Photo: NIH) from HIV infection, the researchers developed a dual-specific CAR-T cell equipped with two types of CAR on a single cell.
    each CAR expresses the extracellular domain of cd4 protein, enabling it to target HIV-infected cells, and the two CARes contain 4-1BB/CD3-ζ and CD28/CD3-ζ inoculates, respectively, which stimulate cell proliferation and persistence, and the latter, which enhances the ability to kill infected cells.
    same time, a membrane fusion inhibitor called C34-CXCR4 is added to the CAR-T cell to prevent HIV attachment and protect CAR-T cells from HIV infection.
    T cell surface is equipped with a schematic of two CAR and membrane fusion inhibitors (Photo Source: Reference 1) So the car-T cells eventually developed by the researchers were able to identify and effectively kill HIV-infected cells, and were resistant to HIV infection.
    in HIV-infected mice, the researchers tested the effects of the new CAR-T cells.
    CAR-T cells slowed HIV replication and infected fewer cells than the untreated control group.
    results of the test on animal blood showed that after treatment, the viral burden of CD4-positive T cells was effectively reduced, meaning that the most important HIV infection target was effectively protected.
    addition, this dual-specific CAR-T cell, combined with existing antiretroviral (ART) drugs, accelerates viral replication in HIV-infected mice, twice as fast as ART alone.
    that this suggests that CAR-T cell therapy can reduce the reservoir of viruses formed in animals during ART.
    Mice receiving both CAR-T cells and ART therapy were completely inhibited after 2 weeks of treatment, and the control group using ART alone took 4 weeks (Photo Source: Reference 1) Summary of the research paper concluded that these results "demonstrate that the new dual-specific CAR-T cell products have a stronger efficacy and potential for effective treatment of HIV infection".
    study used a relatively simple engineering approach to change T-cells, bringing about dramatic changes in efficacy and durability.
    , Professor Riley added, "this finding is important for the use of engineered T cells to fight HIV and cancer."
    " References . . . Colby Maldini et al., (2020) Dual CD4-based CAR T cells with Costimulatory domains of the domains of the property of the virus HIV pathogenesis in vivo. Nature Medicine. DOI: snr Novel Dual CAR T cell immunotherapy holds promise for targeting the HIV reservoir. Retrieved Sep. 2, 2020, from.
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

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