Nature Metabolism: Gut bacteria promote colorectal cancer progression through metabolite formate

Colorectal cancer (CRC) is one of the most common malignant tumors in the world.

In recent years, many studies have confirmed that some gut microbes are related to the occurrence, development and treatment response of colorectal cancer, but these studies are mostly descriptive.

On April 18, 2022, researchers from the University of Luxembourg published a research paper titled: The gut microbial metabolite formate exacerbates colorectal cancer progression in the journal Nature Metabolism .

The study found that Fusobacterium nucleatum (F.

The gut microbiome is a key player in the immunomodulatory and pro-tumor microenvironment during colorectal cancer (CRC), as diverse gut-derived bacteria can induce tumor growth

In this paper, the research team revealed that formate, a metabolite of the colorectal cancer-associated bacterium F.

Co-culture of F.

Experiments in mice have shown that F.

Overall, this paper focuses on the metabolic linkages between gut microbes and the host, demonstrating that formate, a metabolite of the colorectal cancer-associated bacterium F.

Original source:

Ternes, D.