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Nature Metabolism reveals the secrets of cell competition

 Last Update: 2021-07-28
 Source: Internet
 Author: User

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Image: Mouse Embryonic Stem Cells

Source: Anna Lima/Imperial College London

Since multicellular life depends on the interaction between cells, this is not always peaceful, which is not surprising: cells with higher adaptability compete through cell competition to eliminate cells with lower adaptability

The secret recipe to eliminate "loser" cells

The research team found that cells that lost in the competition were characterized by defective mitochondria, while in mouse embryos, their mitochondrial genome sequence changed

In more detail, in the process of gastrulation, mouse embryos use cell competition to remove inappropriate ectodermal cells

Information about the appearance of the "loser" cells in mouse embryos allowed them to determine the identity of the "loser" cells

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This study shows that in various environments where cells compete, mitochondrial activity may be a key determinant of cell fitness

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