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Aging is an intrinsic property of organisms, and the accumulation of damaged proteins in cells is an important feature of organism aging
2021 Nian 6 Yue 14 days, the First Affiliated Hospital of University of Science and Technology of China Center for Brain and brain disease research aging, USTC Life Science and Medicine Department of Xiong Wei professor and research group warehouse Bud cooperation Professor Research Group, in Nature Methods on published title Cover article for " Metabolomic Profiling of Single Enlarged Lysosomes "
Figure .
It is generally believed that the function of lysosomes is impaired during aging, and lysosomal dysfunction may lead to the reduction of lysosomal synthesis and decomposition and other metabolic capacity
It is worth mentioning that, our previous professor Xiong Wei through interdisciplinary cooperation jointly established a single cell mass spectrometry technology and mass spectrometry imaging technologies , for the detection of individual cells within and metabolic group as a whole organ ( PNAS , 2017; the Cell , 2018; Anal Chem , 2019 a , b; Cell Reports , 2020 ; Nature Communications,2021 ) .
Figure single lysosomal metabolomics study analysis platform
For the above related content, please refer to the website of Professor Xiong Wei 's research group ( http://x-lab.
Zhu Hongying, associate professor of the Department of Life Sciences and Medicine, University of Science and Technology of China , PhD students Li Qianqian and Liao Tiepeng are the co- first authors of the paper , and Professor Xiong Wei and Professor Cang Chunlei are the co-corresponding authors of the paper
Original link: https://