Nature: Microbiome regulates intercom neurons through intestinal brain circuits

The connection between the gut and the brain monitors the intestinal tissue and its microorganisms, as well as the content sitabetic content, regulates physiological intestinal functions such as nutrient absorption and movement, and brain-controlled eating behaviorAs a result, it is likely that there is a circuit that detects gut microbes and transmits this information to the central nervous system, which in turn regulates intestinal physiologyhere, the researchers characterized the effects of the microbiome on intestinal-related neuronsBy combining gnotobiotic mouse models with transcriptional genomics, circuit tracking methods, and functional operations, the researchers found that the gut microbiome can regulate intersympathetic neurons on the outside of the gut: the depletion of the microbiome leads to increased expression of neuron transcription factor cFos, and the use of bacteria that produce short-chain fatty acids to plant sterile mice, which inhibits the expression of cFos in the intestinal sympathetic nerve sadgenschemical genetics operations, translation histology and margin tracing identified a subset of distant intestinal projection vagus neurons, which was positioned to have an incoming role in the regulation of intestinal intercom neurons mediated by the microbiomeretrograde multislesoftheli neurons from the intestinal wall identified the brain stem sensory nucleus activated during microbial consumption, as well as the pre-intersectional cyclonine neurons that regulate gastrointestinal transportthese results reveal the microbiome's dependence control over the extraintestinal sympathetic nerve activation through the intestinal brain circuit