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Beginning in 2019, the new crown virus has raged around the world, causing more than 170 million infections and more than 3.
7 million deaths so far
.
Beginning in 2021, many countries around the world have begun universal vaccination of the new crown vaccine, which has played a vital role in controlling the spread of the new crown epidemic
.
When the global epidemic eased slightly, a variety of new variants of the new coronavirus suddenly appeared in India and spread and spread at an alarming rate
.
People are very concerned about whether existing vaccines can protect against these new variants of the new coronavirus infection in India
.
On June 10, 2021, Peiyong Shi’s research team from The University of Texas Medical Branch at Galveston, UTMB, Pfizer and BioNTech from Germany published a titled BNT162b2- Elicited Neutralization of B.
1.
617 and other SARS-CoV-2 Variants (Article)
.
In this study, antiserum from the population immunized with Pfizer’s BNT162b2 vaccine was used against the latest B.
1.
617.
1, two B.
1.
617.
2, B.
1.
618 and five new variants of B.
1.
525 that are popular in Nigeria.
The neutralizing ability of the virus was tested
.
The results show that although the mRNA vaccine antiserum has different degrees of weakening of the neutralizing ability of these variant viruses, it can still effectively resist the infection of these five variants of new coronaviruses
.
In a previous study, Shi Peiyong and Pfizer collaborated to test the changes in the ability of antisera produced by the mRNA vaccine immunized population to neutralize multiple variants of new coronaviruses in the United Kingdom, South Africa, Brazil, and the United States (Nat.
Med.
, Xie et al.
, 2021; NEJM, Liu et al.
, 2021a; NEJM, Liu et al.
, 2021b)
.
In the latest study, the researchers reconstituted the complete surface spike protein of the B.
1.
617 lineage variant virus in India and the B.
1.
525 variant new coronavirus circulating in Nigeria into the original USA WA1/ used for vaccine production.
On the skeleton of the 2020 new coronavirus, the changes in the neutralization ability of the antiserum to the recombinant variant virus are detected
.
The results showed that the ability of antisera to neutralize these variant viruses has decreased to varying degrees.
Among them, the B.
1.
617.
1 variant virus that appeared in early India had the worst protective effect, which was reduced to 30% compared with the control group
.
Even so, all 20 antisera can effectively neutralize all variant viruses and still have sufficient protection
.
The latest Indian variant virus and the results of the serum neutralization experiment of multiple variants of new coronaviruses show that although the antisera induced by the existing mRNA vaccines have a certain range of changes in the neutralization ability of different variant viruses, they can all Maintain a certain protective effect; large-scale vaccination among the population is still the core means to control and end the global new crown epidemic
.
Dr.
Jianying Liu and Dr.
Yang Liu from the University of Texas Medical Branch (UTMB) are the co-first authors of the article
.
Professor Peiyong Shi from the University of Texas Medical Branch (UTMB), Assistant Professor Xuping Xie, Dr.
Dormitzer from Pfizer and Dr.
Sahin from BioNTech are the co-corresponding authors of the article
.
Original link: https:// Plate maker: Notice for reprinting on the 11th [Non-original article] The copyright of this article belongs to the author of the article, personal forwarding and sharing are welcome, and it is prohibited without permission Reprinted, the author has all legal rights, offenders must be investigated
.
7 million deaths so far
.
Beginning in 2021, many countries around the world have begun universal vaccination of the new crown vaccine, which has played a vital role in controlling the spread of the new crown epidemic
.
When the global epidemic eased slightly, a variety of new variants of the new coronavirus suddenly appeared in India and spread and spread at an alarming rate
.
People are very concerned about whether existing vaccines can protect against these new variants of the new coronavirus infection in India
.
On June 10, 2021, Peiyong Shi’s research team from The University of Texas Medical Branch at Galveston, UTMB, Pfizer and BioNTech from Germany published a titled BNT162b2- Elicited Neutralization of B.
1.
617 and other SARS-CoV-2 Variants (Article)
.
In this study, antiserum from the population immunized with Pfizer’s BNT162b2 vaccine was used against the latest B.
1.
617.
1, two B.
1.
617.
2, B.
1.
618 and five new variants of B.
1.
525 that are popular in Nigeria.
The neutralizing ability of the virus was tested
.
The results show that although the mRNA vaccine antiserum has different degrees of weakening of the neutralizing ability of these variant viruses, it can still effectively resist the infection of these five variants of new coronaviruses
.
In a previous study, Shi Peiyong and Pfizer collaborated to test the changes in the ability of antisera produced by the mRNA vaccine immunized population to neutralize multiple variants of new coronaviruses in the United Kingdom, South Africa, Brazil, and the United States (Nat.
Med.
, Xie et al.
, 2021; NEJM, Liu et al.
, 2021a; NEJM, Liu et al.
, 2021b)
.
In the latest study, the researchers reconstituted the complete surface spike protein of the B.
1.
617 lineage variant virus in India and the B.
1.
525 variant new coronavirus circulating in Nigeria into the original USA WA1/ used for vaccine production.
On the skeleton of the 2020 new coronavirus, the changes in the neutralization ability of the antiserum to the recombinant variant virus are detected
.
The results showed that the ability of antisera to neutralize these variant viruses has decreased to varying degrees.
Among them, the B.
1.
617.
1 variant virus that appeared in early India had the worst protective effect, which was reduced to 30% compared with the control group
.
Even so, all 20 antisera can effectively neutralize all variant viruses and still have sufficient protection
.
The latest Indian variant virus and the results of the serum neutralization experiment of multiple variants of new coronaviruses show that although the antisera induced by the existing mRNA vaccines have a certain range of changes in the neutralization ability of different variant viruses, they can all Maintain a certain protective effect; large-scale vaccination among the population is still the core means to control and end the global new crown epidemic
.
Dr.
Jianying Liu and Dr.
Yang Liu from the University of Texas Medical Branch (UTMB) are the co-first authors of the article
.
Professor Peiyong Shi from the University of Texas Medical Branch (UTMB), Assistant Professor Xuping Xie, Dr.
Dormitzer from Pfizer and Dr.
Sahin from BioNTech are the co-corresponding authors of the article
.
Original link: https:// Plate maker: Notice for reprinting on the 11th [Non-original article] The copyright of this article belongs to the author of the article, personal forwarding and sharing are welcome, and it is prohibited without permission Reprinted, the author has all legal rights, offenders must be investigated
.