 Home > Active Ingredient News > Infection > Nature: New coronavirus damages the brain

Nature: New coronavirus damages the brain

 Last Update: 2022-04-19
 Source: Internet
 Author: User

Tags

nervous system review

nervous system medication

Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

Brain-related pathologies exist in COVID-19 , some of which may be the result of viral neurotropism or neuroinflammation following viral infection
.

Most brain imaging studies have focused on the qualitative and gross pathology of moderate to severe cases, most typically in hospitalized patients

COVID-19 COVID-19 has brain-related pathologies, some of which may be the result of viral neurotropism or neuroinflammation following viral infection

A research paper SARS-CoV-2 is associated with changes in brain structure in UK Biobank by Gwenaëlle Douaud of Oxford University, UK, published in the top academic journal "Nature" in the form of Accelerated Article Preview, highlights the new coronavirus (SARS-CoV-2 ) on the nervous system, after infection with the new coronavirus, brain areas related to smell, memory, etc.

This study examined possible brain changes associated with coronavirus infection using multimodal MRI data from 785 adult participants (aged 51 or 81) from the UK Biobank COVID-19 Reimaging Study, with 401 adult participants who tested positive for SARS-CoV-2 infection between scans were included
.

Comparison of longitudinal changes in structural, disseminated, and functional brain scans before and after infection in 401 SARS-CoV-2 cases
.

The cases and 384 controls did not differ in blood pressure, body mass index, diabetes diagnosis

Comparison of longitudinal changes in structural, disseminated, and functional brain scans before and after infection in 401 SARS-CoV-2 cases

(1)(1) More significant reductions in gray matter thickness and contrast in lateral orbitofrontal cortex and parahippocampal gyrus (min P = 1.

(2)(2 ) Relative increases in diffusion index (a marker of tissue damage) in brain regions functionally connected to the piriform cortex, anterior olfactory nucleus, and olfactory tubercle (min P=2.

(3) (3) Greater reduction in brain volume and increase in cerebrospinal fluid volume, suggesting diffuse brain atrophy was also present in infected participants (min P=4.

These gray matter thickness results covered the parahippocampal gyrus and the lateral orbitofrontal cortex, and extended into the anterior insula and anterior cingulate cortex, the supramarginal gyrus, and the temporal pole

Increases in the diffusion index (mean diffusivity) were mainly seen in the medial and lateral orbitofrontal cortex, anterior insula, anterior cingulate cortex, and amygdala

Intergroup Comparison of Longitudinal Changes in Cortical Thickness

The gray matter thickness in the fronto-parietal and temporal lobe regions was significantly reduced in SARS-CoV-2 patients .
The 401 participants infected with SARS-CoV-2 also showed greater cognitive decline between the two time points compared to the control group .
In addition to the affected limbic and olfactory cortical systems, cognitive decline was also associated with increased atrophy of brain regions in the cerebellum and associated with cognitive function .

SARS-CoV-2 SARS-CoV-2 patients had significantly reduced gray matter thickness in fronto-parietal and temporal lobe regions
.

The 401 participants infected with SARS-CoV-2 also showed greater cognitive decline between the two time points compared to the control group

The study revealed a spatial pattern: The limbic brain region that forms the main olfactory network changes abnormally after infection with COVID-19

original source

Douaud G, Lee S, Alfaro-Almagro F, et al.
SARS-CoV-2 is associated with changes in brain structure in UK Biobank.
Preprint.
medRxiv .
2022;2021.
06.
11.
21258690.
Published 2022 Mar 2.
doi:10.
1101/2021.
06 .
11.
21258690 Douaud G, Lee S, Alfaro-Almagro F, et al.
SARS-CoV-2 is associated with changes in brain structure in UK Biobank.
Preprint.
medRxiv Comments here

This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.