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    Home > Active Ingredient News > Infection > Nature: New coronavirus variant Delta is less sensitive to antibodies 

    Nature: New coronavirus variant Delta is less sensitive to antibodies 

    • Last Update: 2021-07-29
    • Source: Internet
    • Author: User
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    The new coronavirus variant SARS-CoV-2 B.
    1.
    617 was confirmed in India in October 2020

    .
    Since then, it has become dominant in some areas of India and the United Kingdom, and has further spread to many countries

    .
    The strain includes three main subtypes (B1.
    617.
    1, B.
    1.
    617.
    2 and B.
    1.
    617.
    3), with different spike mutations in the N-terminal domain (NTD) and the receptor binding domain (RBD) , Which may increase its
    immune evasion potential
    .

    immunity

    B.
    1.
    617.
    2, also known as variant Delta, is believed to spread faster than other variants

    .
    The Delta variant has been detected in many countries

    .
    It already dominates in Maharashtra and possibly other Indian regions

    .
    In addition, this variant accounted for 77% of the transmitted viruses sequenced in the UK between June 2-9, 2021

    .
    It has been classified as a variant of concern (VOC) and is believed to be 60% more transmissible than the variant Alpha

    .

    At present, little is known about the sensitivity of the variant Delta to the humoral immune response
    .
    Recent reports indicate that members of the B.
    1.
    617 line are less sensitive to certain monoclonal and polyclonal antibodies

    .

    Recently, researchers isolated an infectious Delta strain from a traveler returning from India and studied its sensitivity to monoclonal antibodies (mAbs) and antibodies in the sera of COVID-19 survivors or vaccine recipients Sex, and compared with other virus strains
    .

    COVID-19

    The results show that the variant Delta is resistant to neutralization of some anti-NTD and anti-RBD mAbs (including Bamlanivimab), and the binding of these mAbs to Spike is affected
    .
    The efficacy of the convalescent patient's serum collected within 12 months after the onset of symptoms on the variant Delta is 4 times lower than that of the variant Alpha (B.
    1.
    1.
    7)

    .

    Some anti-Delta variants and anti-NTD of RBD mAbs (including Bamlanivimab) neutralization resistant variants of anti-Delta some of NTD and mAbs anti-RBD (including Bamlanivimab) and resistant in sera of patients recovering the variant The efficacy of Delta is 4 times lower than that of variant Alpha .
    The serum of convalescent patients is 4 times lower than that of variant Alpha.

    New coronavirus variants are neutralized by therapeutic antibodies

    The case where the new coronavirus variant is neutralized by the therapeutic antibody The case where the new coronavirus variant is neutralized by the therapeutic antibody

    In addition, the sera of people who have received a dose of Pfizer or AstraZeneca vaccine have almost no inhibitory effect on the variant Delta
    .
    After using two doses of the vaccine, 95% of people had a neutralization reaction, but the titre to Delta was 3 to 5 times lower than that of Alpha

    .

    The serum of a person who has received a dose of Pfizer or AstraZeneca vaccine has almost no inhibitory effect on the variant Delta.
    The serum of a person who has received a dose of Pfizer or AstraZeneca vaccine has almost no inhibitory effect on the variant Delta.

    Therefore, the results of this study indicate that the spread of variant Delta is related to evading antibodies against non-RBD and RBD spike epitopes
    .

     

    Original source:

    Original source:

    Delphine Planas et al.
    Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization.
    Nature
    (2 021).
     

    Delphine Planas et al.
    Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization.
    Nature
    Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization.
    (2 021).
     
     

     

     



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