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This article is converted Medicine original, reproduced please indicate the source Author: chen Introduction: Autism is difficult to cure, it is a lifelong neurodevelopmental disorder of.
Researchers from the University of Ottawa School of Medicine found that by increasing the norepinephrine in the motor cortex, the mice's motor skills improved faster, hoping to provide a new idea for helping children with autism.
Autism, also called autism, is a neurodevelopmental disorder that appears in early childhood development and lasts for life.
Many studies have shown that autism is highly heritable, and its heritability is as high as 80%.
According to data from the US Centers for Disease Control and Prevention in 2020, 1 out of 54 children has autism, and there are more boys than girls.
In literary works, children with autism are often referred to as "children of the stars" because they twinkle alone like stars in the distant night sky and cannot communicate normally with the outside world.
Their clinical manifestations include: (1) social communication disorder (2) language communication disorder (3) repetitive stereotyped behaviors and so on.
In October 2019, researchers proposed that the active sensory cortex is necessary to consolidate or retain new motor skills for human learning motor skills.
The storage of the latest body information accumulated in the process is essential for maintenance and subsequent reuse.
This also provides new ideas for scientists to study autism spectrum disorders.Recently, researchers at the University of Ottawa’s Faculty of Medicine have studied the neurological basis of motor learning delay and published a new study in the journal Nature Neuroscience entitled “Delayed motor learning in a 16p11.
2 deletion mouse model of autism is rescued by locus coeruleus activation ".
Studies have shown that slow motor learning is caused by an insufficient amount of norepinephrine released into the main motor cortex of the brain, and is derived from norepinephrine in the locus coeruleus region (ie, motivation, alertness, and attention centers) in the back of the brain.
Locus coeruleus is an area in the brain that releases norepinephrine, which can make people more alert.
The researchers imaged the mouse brain in real time in a mouse model of autism.
They found that there was a delay in the process of clearing the old basal and forming a new basal in the brain of mice, which caused confusion in the brain.
That is, the brain does not know what signal to process because it delays in removing unnecessary old substrates.
Therefore, it is relatively slow for rats to learn correct movements.
Next, the scientists let the mice learn to run on a rotating disc.
Their heads are fixed, so they need to learn how to adjust their bodies to run.
At first, it was difficult for them to control their body posture (Video 1).
But after 12 days, they learned how to control their bodies and are now able to run smoothly on the turntable (Video 2).
Video 1 The first day of mice running on the disc Video 2 The 12th day of mice running on the disc So, how did the mice never run on the disc to run smoothly? When the researchers injected an artificial drug into the mouse's abdomen to increase the release of norepinephrine, the mouse's behavior was rescued.
But isn't it because the mice pay more attention to tasks that make them do faster? Then, the researchers injected artificial drugs into the motor cortex to activate the axons of the locus coeruleus nucleus, and the behavior of the mice was rescued again.
This suggests that it is not because the mice are more focused, but because the drugs make them better in learning tasks.
The motor cortex lacks norepinephrine.
If we supplement enough norepinephrine in the motor cortex, mice can learn.
All in all, by increasing the norepinephrine in the motor cortex, the mice’s motor skills improved faster; drugs that activate the locus coeruleus noradrenergic neurons are sufficient to save these mice’s circuit defects and delayed motor learning.
Perhaps one day we can find a treatment to increase the patient's norepinephrine level, which is of great significance for solving the delayed motor learning of children with autism.
Reference materials: [1] https:// [2] https://medicalxpress.
com/news/2021-03-root-motor-autism.
html recommended Read [New Development] The upgraded version of "Starve Cancer Cells" is here! Scientists have discovered that a drug can inhibit the growth of melanoma, which is also applicable to other cancers [First round of guest announcement] 2021 Second Single Cell Sequencing Technology Application Forum invites you to participate! [New Research] Will it be overwhelmingly bright? Muscle stem cell therapy or the first case of New Gospel 【Nature Back-to-Back】! Construct a complete human embryo model under laboratory conditions.
Click here to read the original text
Researchers from the University of Ottawa School of Medicine found that by increasing the norepinephrine in the motor cortex, the mice's motor skills improved faster, hoping to provide a new idea for helping children with autism.
Autism, also called autism, is a neurodevelopmental disorder that appears in early childhood development and lasts for life.
Many studies have shown that autism is highly heritable, and its heritability is as high as 80%.
According to data from the US Centers for Disease Control and Prevention in 2020, 1 out of 54 children has autism, and there are more boys than girls.
In literary works, children with autism are often referred to as "children of the stars" because they twinkle alone like stars in the distant night sky and cannot communicate normally with the outside world.
Their clinical manifestations include: (1) social communication disorder (2) language communication disorder (3) repetitive stereotyped behaviors and so on.
In October 2019, researchers proposed that the active sensory cortex is necessary to consolidate or retain new motor skills for human learning motor skills.
The storage of the latest body information accumulated in the process is essential for maintenance and subsequent reuse.
This also provides new ideas for scientists to study autism spectrum disorders.Recently, researchers at the University of Ottawa’s Faculty of Medicine have studied the neurological basis of motor learning delay and published a new study in the journal Nature Neuroscience entitled “Delayed motor learning in a 16p11.
2 deletion mouse model of autism is rescued by locus coeruleus activation ".
Studies have shown that slow motor learning is caused by an insufficient amount of norepinephrine released into the main motor cortex of the brain, and is derived from norepinephrine in the locus coeruleus region (ie, motivation, alertness, and attention centers) in the back of the brain.
Locus coeruleus is an area in the brain that releases norepinephrine, which can make people more alert.
The researchers imaged the mouse brain in real time in a mouse model of autism.
They found that there was a delay in the process of clearing the old basal and forming a new basal in the brain of mice, which caused confusion in the brain.
That is, the brain does not know what signal to process because it delays in removing unnecessary old substrates.
Therefore, it is relatively slow for rats to learn correct movements.
Next, the scientists let the mice learn to run on a rotating disc.
Their heads are fixed, so they need to learn how to adjust their bodies to run.
At first, it was difficult for them to control their body posture (Video 1).
But after 12 days, they learned how to control their bodies and are now able to run smoothly on the turntable (Video 2).
Video 1 The first day of mice running on the disc Video 2 The 12th day of mice running on the disc So, how did the mice never run on the disc to run smoothly? When the researchers injected an artificial drug into the mouse's abdomen to increase the release of norepinephrine, the mouse's behavior was rescued.
But isn't it because the mice pay more attention to tasks that make them do faster? Then, the researchers injected artificial drugs into the motor cortex to activate the axons of the locus coeruleus nucleus, and the behavior of the mice was rescued again.
This suggests that it is not because the mice are more focused, but because the drugs make them better in learning tasks.
The motor cortex lacks norepinephrine.
If we supplement enough norepinephrine in the motor cortex, mice can learn.
All in all, by increasing the norepinephrine in the motor cortex, the mice’s motor skills improved faster; drugs that activate the locus coeruleus noradrenergic neurons are sufficient to save these mice’s circuit defects and delayed motor learning.
Perhaps one day we can find a treatment to increase the patient's norepinephrine level, which is of great significance for solving the delayed motor learning of children with autism.
Reference materials: [1] https:// [2] https://medicalxpress.
com/news/2021-03-root-motor-autism.
html recommended Read [New Development] The upgraded version of "Starve Cancer Cells" is here! Scientists have discovered that a drug can inhibit the growth of melanoma, which is also applicable to other cancers [First round of guest announcement] 2021 Second Single Cell Sequencing Technology Application Forum invites you to participate! [New Research] Will it be overwhelmingly bright? Muscle stem cell therapy or the first case of New Gospel 【Nature Back-to-Back】! Construct a complete human embryo model under laboratory conditions.
Click here to read the original text
