Nature of Central South University published an article: A novel metabolic mechanism of iron death in tumor cells

Professor Yang Minghua's team of Pediatrics from the Third Xiangya Hospital of Central South University published original research results entitled "The lipid flippase SLC47A1 blocks metabolic vulnerability to ferroptosis" in the international authoritative academic journal Nature Communications, revealing the novel metabolic mechanism of iron death in tumor cells.
For the first time, a new strategy
targeting SLC47A1-mediated lipid metabolism reprogramming to induce ferrozois was elucidated.
Professor Yang Minghua and Professor Tang Daolin of Southwest Medical Center are the co-corresponding authors of the paper, Lin Zhi, a 2019 doctoral student from the Third Xiangya Hospital of Central South University, is the first author, and the Third Xiangya Hospital is the first author
.
The research results were supported
by the National Natural Science Foundation of China and the Third Xiangya Hospital Huizhi Education Talents.

Targeting SLC47A1-mediated lipid metabolism reprogramming induces ferrozoosis

Abnormal lipid metabolism is one of the important features of cancer, and lipids are also oxidized substrates when ferrozois occurs, and targeted lipid metabolism reprogramming to induce ferrozois is becoming a new strategy
for tumor treatment.
Phospholipid transportases are key molecules that transport phospholipids inside and outside cell membranes and are particularly important
for maintaining membrane fluidity and intracellular lipid homeostasis.
This study identified for the first time a phospholipid transportase molecule (SLC47A1) involved in regulating ferrozois in tumor cells, elucidated the key pathway of SLC47A1 in regulating ferrozoosis, revealed a novel metabolic mechanism of ferrozoosis, and enriched the regulatory network of ferrozogenesis, providing new ideas
for targeted therapy of various tumors including pancreatic cancer and acute leukemia.