"Nature" published a paper revealing a new mechanism for disease-causing bacteria to evade innate immunity

Since we were young, we have known that we must pay attention to hygiene and avoid "disease in the mouth", because many bacteria in nature, once they break through the body's immune defenses, may cause diseases

Understanding how pathogenic bacteria infect host cells and how host cells resist pathogenic bacteria is the basis for providing methods to prevent and treat diseases

In the field of anti-bacterial natural immunity, Dr.

Recently, Dr.

In previous studies, Dr.

However, for their own survival, pathogenic bacteria and host cells have been fighting each other

The research team found that, although the caspase-11 in mouse cells played a key role in the process of pathogen-induced pyrolysis, it could not protect mice from Shigella flexneri infection

After screening several effector molecules that Shigella may be used to inhibit the caspase signaling pathway, the researchers identified the effector protein OspC3 secreted by the bacteria, which may be an important weapon with this escape ability, which can inhibit LPS induction.

While continuing to explore the mechanism of how OspC3 inhibits caspase function, researchers made unexpected discoveries

Specifically, this post-translational modification at first glance is quite similar to the ADP-ribosylation (ADP-ribosylation) discovered decades ago.

▲Researchers have discovered a new protein post-translational modification: ADP-riboxanation (picture source: reference [1])

The researchers proved in this paper that when caspase-11 undergoes ADP-riboxanation, it can no longer automatically process and recognize and cut GSDMD, resulting in the innate immunity mediated by pyroptosis cannot play its due role

As a result, the research team solved the mystery of how the pathogenic bacteria Shigella escapes innate immunity

Note: The original text has been deleted

Reference materials:

[1] Zilin Li et al.

[2] Shao Feng/Liu Xiaoyun’s team reveals a new mechanism by which pathogens inhibit host cell pyrolysis-a new protein post-translational modification Retrieved Nov.