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    Home > Biochemistry News > Biotechnology News > Nature: RAS hijacks nutrients to keep pancreatic cancer cells from starving

    Nature: RAS hijacks nutrients to keep pancreatic cancer cells from starving

    • Last Update: 2020-05-31
    • Source: Internet
    • Author: User
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    Photo from Nature, 2019, doi:10.1038/s41586-019-1831-xthis process is called macropinocytosis, a process that devours proteins and fats that are broken down to produce amino acids and metabolites that can be used to build new proteins, DNA strands, and cell membranesWithout these amino acids and metabolites, cancer cells cannot proliferate"We found a mechanism associated with the supply of nutrients that we believe gives RAS mutant tumor cells a critical survival mechanism," said DrCraig Ramirez, lead author of thepaper and a postdoctoral fellow in the Department of Biochemistry and Molecular Biology at New York University School of Medicinespecifically, the researchers found that the RAS mutation further activated the SLC4A7 protein, which allowed a protein called bicarbonate-dependent soluble adenosine cyclase to activate protein kinase AThis in turn changed the position of the enzyme v-ATPaseby transferring v-ATPase from the depths of cells to near their outer membranes, the researchers said, the transfer makes the enzyme suitable for the delivery of cholesterol needed to attach RAC1 to the cell membraneThe accumulation of v-ATPase near the outer membrane and the associated positioning of Rac1 cause the cell membrane to temporarily bulge, roll and form a vesicuriate that devours nutrients during the process of cytomesin cell culture studies, treating RAS mutant tumor cells with SLC4 protein family inhibitor S0859 led to a significant reduction in the positioning of the v-ATPase exdomephalate, which can lead to RAS dependence, and inhibited microcytosisin addition,analysis of molecular data from human pancreatic cancer (PDAC) tissue showed that the gene encoded SLC4A7 was four times more expressive in tumors than normal nearpan pancreatic tissuethe researchers also found that the SLC4A7 gene in silent pancreatic cancer cells could slow down or shrink tumors in mice"We are now looking for candidate drugs that could inhibit SLC4A7 or v-ATPase, which could be potential treatments for the future of stopping the effects of giant trolls," said DrDafna Bar-Sagi of New York University School of Medicine, apaper Both proteins are good targets in principle because they are associated with the growth of cancer and work near the surface of cancer cells, where they can be reached by blood-borne drugs References: 1 Craig Ramirez et al Plasma p P V-ATPase Controls oncogenic RAS-induced macropinocytosis Nature, 2019, doi:10.1038/s41586-019-1831-x 2.Mechanisms help pancreatic cancer cancer avert sage https://medicalxpress.com/news/2019-12-mechanisms-pancreatic-cancer-cells-avert.html original title: Nature: RAS mutation activates the giant drinking effect stoic sedation of pancreatic cancer cells, so that they avoid starvation
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