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    Home > Active Ingredient News > Immunology News > Nature: reveal the mechanism that causes irritable bowel syndrome

    Nature: reveal the mechanism that causes irritable bowel syndrome

    • Last Update: 2021-01-27
    • Source: Internet
    • Author: User
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    JANUARY 18, 2021 /--- In a new study, researchers from the University of Leuven in Belgium identified biological mechanisms that explain why some people experience abdominal pain when eating certain foods.
    the findings pave the way for more effective treatment of irritable bowel syndrome (IBS) and other food insatiability.
    study in mice and humans was published online January 13, 2021 in the journal Nature under the title "Local immune to food antigens drive meal-induced abdominal pain."
    photo from Nature, 2021, doi:10.1038/s41586-020-03118-2.
    up to 20 per cent of the world's population suffers from irritable bowel syndrome, a condition that causes stomach pain or severe discomfort after eating.
    affected their quality of life.
    gluten-free diet and other diets can provide some relief, but given that patients are not allergic to these foods and have no known diseases, such as celiac disease, why this works is a mystery. Professor Guy Boeckxstaens, a gastroenterologist at the University of Leuven and author of the
    paper, said: "Normally, these patients are not taken seriously by doctors, and the lack of allergic reactions is used to confirm that it is all psychological and that there is no problem with their intestinal physiology.
    through these new insights, we provide further evidence that we are dealing with a real disease.
    and clinical studies by
    " histamine Boeckxstaens and their team have revealed a mechanism that linkes certain foods to the activation of cells that release histamines, called fat cells, and subsequent pain and discomfort.
    their previous research have shown that blocking an important component of the immune system called histamines can improve symptoms in patients with irritable bowel syndrome.
    in a healthy gut, the immune system doesn't respond to food, so the first step is to find out what causes this toy damage.
    Because patients with irritable bowel syndrome often report that their symptoms occur after a gastrointestinal infection, such as food poisoning, the researchers initially thought that when there was a specific food in the gut, the infection might make the immune system sensitive to the food.
    they infected the mice with bacteria and fed them albumin.
    egg white protein is a protein found in egg whites and is commonly used as a food antigen model in experiments.
    is any molecule that triggers an immune response.
    the infection was cleared, the mice were injected with albumin again to see if their immune systems were already sensitive to it.
    results are positive: albumin itself can trigger hypertrophic cell activation, histamine release and digestive insanity, and increased abdominal pain.
    mice that received albumin without a bacterial infection did not have this condition.
    a series of food-related immune diseases, the researchers were then able to crack a series of events in the immune response that linked the intake of egg white protein to the activation of fat cells.
    it is worth noting that this immune response occurs only in the intestinal part of the intestine infected by destructive bacteria.
    it did not produce more common food allergies.
    Boeckxstaens speculates that this points to a range of food-related immune diseases.
    some of these diseases, the immune response to food antigens is very local, such as irritable bowel syndrome.
    in other diseases, fat cells are overactive and have effects on breathing, blood pressure, etc., such as food allergies.
    the researchers then continued to look at whether patients with irritable bowel syndrome had the same response.
    When food antigens (gluten, wheat, soy and cow's milk) associated with irritable bowel syndrome were injected into the intestinal walls of 12 patients with irritable bowel syndrome, they developed a local immune response similar to that of mice.
    healthy volunteers did not respond.
    relatively small number of participants means that the findings need to be further confirmed, but they are important if considered in combination with earlier clinical trials showing improvements in patients with irritable bowel syndrome during treatment with antihistamines.
    Boeckxstaens, said: "This is further evidence that the mechanisms we have revealed are clinically significant.
    ", a larger clinical trial of antihistamine therapy is under way.
    , "but it's important to understand the mechanisms that cause fat cell activation, which will lead to new treatments for these patients," he added.
    fat cells release much more compounds and media than histamines, so if you can stop these cells from activating, I'm sure you'll have a more effective treatment.
    " (Bioon.com) Reference: 1.Javier Aguilera-Lizarraga et al. Local immune response to food antigens drives meal-induced abdominal pain. Nature, 2021, doi:10.1038/s41586-020-03118-2.2.Scientists reveal mechanism that causes irritable bowel syndrome
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