【Nature Sub-issue】Be careful!

This article was originally written by Translational Medicine.
Please indicate the source Author: Ashley Introduction: Triclosan is a common antibacterial agent that exists in thousands of products such as toothpaste
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A recent study in mice demonstrated that triclosan is triggered by specific gut microbial enzymes to damage the gut, leading to inflammatory bowel disease (the incidence and prevalence of inflammatory bowel disease in the increased sharply over the years)
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Therefore, the safety of triclosan should be widely paid attention to
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A new study in mice shows exactly how triclosan, an antibacterial agent found in toothpaste, toys and thousands of other products, triggers inflammation in the gut
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An international team of researchers led by the University of North Carolina at Chapel Hill, the University of Massachusetts Amherst and Hong Kong Baptist University has identified the bacteria, and even a specific enzyme, that triggers the harmful effects of triclosan
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In addition, studies in mice show that these bacterial enzymes can be blocked to drive intestinal damage
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The findings, titled "Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract," were published in the journal Nature Communications
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"By identifying disease-causing bacteria, new methods for diagnosing, preventing and treating inflammatory bowel disease could be developed," said study author Matthew Redinbo, professor of chemistry and microbiology in UNC-Chapel Hill's College of Arts and Sciences and UNC School of Medicine.
method
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Previous studies have shown the toxicity of triclosan, but the new study provides a closer look at changes in gut microbial populations
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The
researchers identified specific gut microbial enzymes, specifically gut microbial beta-glucural Glucosidase (GUS) proteins are linked to triclosan and have shown that these enzymes drive triclosan to wreak havoc in the gut
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After knowing which bacterial proteins were to blame, the team used a microbe-targeted inhibitor to prevent the Blocks the effects of triclosan in the gut
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Blocking this process in mice prevents colon damage and symptoms of colitis, an inflammatory bowel disease, IBD
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The study adds to the growing number of people diagnosed with IBD Population provides new clues about treatment for IBD
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IBD flares up in seemingly ubiquitous conditions, requiring long-term treatment
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Study authors suggest a better understanding of the impact of environmental chemicals on gut health is needed
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Triclosan has been widely used used in antibacterial soaps sold to consumers
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But in 2016, the U.
S.
Food and Drug Administration (FDA) ordered its removal from handwashing products used in home and hospital settings amid concerns it would lead to more drug-resistant bacteria in addition
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However, triclosan as an additive to cosmetics, yoga mats and other sports apparel and equipment to reduce bacterial contamination of ingredients is still everywhere
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it is also used in many conventional toothpaste approved by the FDA because it was found to be Prevents gingivitis
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Triclosan appears to be readily absorbed in the gastrointestinal tract, and lead study authors write, "Given the potential for intestinal damage, triclosan and related compounds should reconsider their safety profile
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"The National Institutes of Health funded several authors, and the Hong Kong Research Grants Council and the National Science Foundation funded the study "Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract
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"
Reference: https://medicalxpress .
com/news/2022-01-reveals-triclosan-toothpaste-triggered-gut.
html Note: This article is intended to introduce the progress of medical research and cannot be used as a reference for treatment plans
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If you need health guidance, please go to a regular hospital for treatment
.

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