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This article is original for Translational Medicine.
Please indicate the source when reprinting.
Author: Jasmine Introduction: 3D organoids are one of the revolutionary developments in the field of biomedicine in the past decade
.
Intestinal organoids are fundamental in vitro tools that provide new research methods for intestinal stem cell research
.
Not only that, but organoids can also be transplanted into the body as a preclinical tool for disease modeling and regenerative medicine
.
3D organoids, one of the revolutionary developments in biomedicine in the past decade
.
3D organoids are shrunken and simplified versions of (lab-produced) organs, made up of clumps of cells
.
They are three-dimensional and capable of displaying realistic microscopic anatomy
.
Organoids are widely used as in vitro tools to study disease, as well as for regenerative medicine and precision medicine
.
Back in 2009, Hans Clevers and Toshiro Sato created the first mini-guts organoids using adult stem cells derived from the mouse gut
.
Later, they extended this approach to the culture of human epithelial organoids
.
These organoids may give researchers new insights into gut health and disease, including colorectal cancer
.
Ulcerative colitis is a type of inflammatory bowel disease (IBD) that causes digestive problems and ulcers, mainly in the innermost layers of the colon and rectum
.
Ulcerative colitis can become debilitating and even die from the severe complications it causes
.
Most importantly, there is currently no cure
.
Recently, researchers from Tokyo Medical and Dental University (TMDU) have proposed a detailed scientific experimental protocol for the treatment of ulcerative colitis, which is to regenerate intestinal tissue damaged in colitis by transplanting 3D organoids
.
They experimented with a mouse model of colitis obtained by administering sodium dextran sulfate, which destroys the intestinal epithelium in a manner similar to colitis
.
The results of the study were published in "Nature protocols", entitled: "Transplantation of intestinal organoids into a mouse model of colitis"
.
https://doi.
org/10.
1038/s41596-021-00658-3 In experiments, the researchers replaced damaged intestinal tissue with intestinal organoids, an application of regenerative medicine
.
Satoshi Watanabe, lead author of the paper, explained: "We used a flexible catheter to infuse approximately 1,000 organoids into the colon where the most epithelial damage occurred.
Epithelial tissue (i.
e.
the layers of cells inside the colon) combine
.
Ultimately an intact epithelial tissue is formed in which part of the recipient's epithelial layer has been replaced by donor cells
.
" The total time for infusion into the organoid is only 10 minutes, which is more important Surprisingly, the researchers found that the method was repeatable under different organoid culture conditions
.
Therefore, the infusion of organoids is fast, reproducible, and minimally invasive, which also makes it very attractive for clinical applications
.
In addition, organoids can also be extracted from recipient patients' cells, thereby minimizing post-transplant rejection
.
The study lays the groundwork for a human clinical trial using colon organoid transplantation to treat severe ulcerative colitis
.
Today, the protocol developed in this study has been translated into clinical practice, and both the scientific and clinical communities are excited about future clinical applications
.
Reference: https://medicalxpress.
com/news/2022-02-infusion-3d-cellular-intestine.
html Note: This article aims to introduce the progress of medical research and cannot be used as a reference for treatment plans
.
For health guidance, please go to a regular hospital for treatment
.
Recommendation·Event The first Yangtze River Delta single-cell omics technology application forum "Drug Precision" series of live broadcasts: the second phase of MRD detection and Car-T cell therapy development popular articles Organoid research [year-end inventory] must-see in the field of organoids in 2021 Essential Research Content Medical Research [Cell Sub-Journal] Optimization Technology! Restore human cells to stem cell state! Cancer Research [Science Sub-Journal] Will "lactic acid" help cancer cells? Studies have found that specific enzymes can fight it! Genetic Testing【Science Sub-Journal】A previously unknown gene mutation, BAG5, can cause incurable heart disease cancer research 【Science Sub-Journal】“Pseudogene” carcinogenic? Research identifies a new pathway leading to liver cancer -- pseudogene demethylation, which could help develop new treatments! New research shows how to test the effectiveness of anti-cancer drugs
Please indicate the source when reprinting.
Author: Jasmine Introduction: 3D organoids are one of the revolutionary developments in the field of biomedicine in the past decade
.
Intestinal organoids are fundamental in vitro tools that provide new research methods for intestinal stem cell research
.
Not only that, but organoids can also be transplanted into the body as a preclinical tool for disease modeling and regenerative medicine
.
3D organoids, one of the revolutionary developments in biomedicine in the past decade
.
3D organoids are shrunken and simplified versions of (lab-produced) organs, made up of clumps of cells
.
They are three-dimensional and capable of displaying realistic microscopic anatomy
.
Organoids are widely used as in vitro tools to study disease, as well as for regenerative medicine and precision medicine
.
Back in 2009, Hans Clevers and Toshiro Sato created the first mini-guts organoids using adult stem cells derived from the mouse gut
.
Later, they extended this approach to the culture of human epithelial organoids
.
These organoids may give researchers new insights into gut health and disease, including colorectal cancer
.
Ulcerative colitis is a type of inflammatory bowel disease (IBD) that causes digestive problems and ulcers, mainly in the innermost layers of the colon and rectum
.
Ulcerative colitis can become debilitating and even die from the severe complications it causes
.
Most importantly, there is currently no cure
.
Recently, researchers from Tokyo Medical and Dental University (TMDU) have proposed a detailed scientific experimental protocol for the treatment of ulcerative colitis, which is to regenerate intestinal tissue damaged in colitis by transplanting 3D organoids
.
They experimented with a mouse model of colitis obtained by administering sodium dextran sulfate, which destroys the intestinal epithelium in a manner similar to colitis
.
The results of the study were published in "Nature protocols", entitled: "Transplantation of intestinal organoids into a mouse model of colitis"
.
https://doi.
org/10.
1038/s41596-021-00658-3 In experiments, the researchers replaced damaged intestinal tissue with intestinal organoids, an application of regenerative medicine
.
Satoshi Watanabe, lead author of the paper, explained: "We used a flexible catheter to infuse approximately 1,000 organoids into the colon where the most epithelial damage occurred.
Epithelial tissue (i.
e.
the layers of cells inside the colon) combine
.
Ultimately an intact epithelial tissue is formed in which part of the recipient's epithelial layer has been replaced by donor cells
.
" The total time for infusion into the organoid is only 10 minutes, which is more important Surprisingly, the researchers found that the method was repeatable under different organoid culture conditions
.
Therefore, the infusion of organoids is fast, reproducible, and minimally invasive, which also makes it very attractive for clinical applications
.
In addition, organoids can also be extracted from recipient patients' cells, thereby minimizing post-transplant rejection
.
The study lays the groundwork for a human clinical trial using colon organoid transplantation to treat severe ulcerative colitis
.
Today, the protocol developed in this study has been translated into clinical practice, and both the scientific and clinical communities are excited about future clinical applications
.
Reference: https://medicalxpress.
com/news/2022-02-infusion-3d-cellular-intestine.
html Note: This article aims to introduce the progress of medical research and cannot be used as a reference for treatment plans
.
For health guidance, please go to a regular hospital for treatment
.
Recommendation·Event The first Yangtze River Delta single-cell omics technology application forum "Drug Precision" series of live broadcasts: the second phase of MRD detection and Car-T cell therapy development popular articles Organoid research [year-end inventory] must-see in the field of organoids in 2021 Essential Research Content Medical Research [Cell Sub-Journal] Optimization Technology! Restore human cells to stem cell state! Cancer Research [Science Sub-Journal] Will "lactic acid" help cancer cells? Studies have found that specific enzymes can fight it! Genetic Testing【Science Sub-Journal】A previously unknown gene mutation, BAG5, can cause incurable heart disease cancer research 【Science Sub-Journal】“Pseudogene” carcinogenic? Research identifies a new pathway leading to liver cancer -- pseudogene demethylation, which could help develop new treatments! New research shows how to test the effectiveness of anti-cancer drugs
