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Recently, researchers from the Garvan Institute of Medical Research published an article titled Peripheral-specific Y1 receptor antagonism increases thermogenesis and protects against diet-induced obesity in the journal Nature Communications.
Neuropeptide Y (NPY) is an important obesity-promoting factor, which is widely distributed in the central and peripheral nervous system.
When blocking the neuropeptide Y-Y1 receptor (NPY-Y1R), it can prevent the receptor in adipose tissue from converting "energy storage" fat into "energy consumption" fat, thereby promoting fat metabolism and preventing weight gain.
In this latest study, researchers fed wild-type (WT) C57Bl/6JAusb mice on a high-dose high-fat diet (HFD) for 7 weeks, and at the same time took the Y1 selective antagonist BIBO3304.
In order to further prove the importance of Y1 receptors, the researchers applied BIBO3304 to fat cells isolated from the human body.
The expression of Y1R mRNA in mouse and human adipose tissue and the influence of peripheral Y1R antagonism on the body weight and body composition of wild-type mice
Not only that, the researchers also found that the development of obesity is promoted by surrounding Y1R signaling.
Y1R signaling in adipose tissue is essential for the development of obesity
As we all know, the NPY system is famous for its conservation during evolution, but is the role of YIR signaling in human adipose tissue also conservative?
To prove their conjecture, the researchers collected subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) from normal and obese adult subjects, and analyzed the mRNA expression of thermogenesis markers in SAT and VAT based on qPCR technology.
The study found that in obese patients’ SAT and VAT, the mRNA expression of key thermogenic genes (such as UCP1, PGC1α, Cidea, CD137 and Tmem26), adiponectin and adipocyte-specific gene PPARγ were significantly down-regulated .
Peripheral Y1R antagonism activates thermogenesis in human adipocytes
Currently, most prescription drugs for weight loss reduce food intake by targeting the central nervous system.
Therefore, this research is of great significance.
Reference materials:
[1]https://