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    Home > Active Ingredient News > Infection > [Nature Sub-Journal] Constructing a blueprint for the structure of "Trojan Horse" nanoparticles, which has broad application prospects and is expected to become a new method for the treatment of COVID-19!

    [Nature Sub-Journal] Constructing a blueprint for the structure of "Trojan Horse" nanoparticles, which has broad application prospects and is expected to become a new method for the treatment of COVID-19!

    • Last Update: 2022-01-09
    • Source: Internet
    • Author: User
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    This article is original by Translational Medicine.
    Please indicate the source for reprinting.
    Author: Liz Zee Guide: The COVID-19 pandemic highlights the devastating effects of acute lung injury (ALI), which is part of acute respiratory distress syndrome (ARDS) , And ARDS is the leading cause of death among COVID-19 patients
    .

    Recently, researchers have discovered a potential new method for diagnosing and treating ARDS
    .

    According to a new study from the Perelman School of Medicine at the University of Pennsylvania-How neutrophils (a type of white blood cells that detect and remove harmful particles from the body) distinguish the substances to be removed by the surface structure of the substances, and are more inclined to remove them Those "protein aggregation" particles, researchers have discovered a potential new method for the diagnosis and treatment of acute respiratory distress syndrome (ARDS)
    .

    The research results were published in "Nature Nanotechnology" under the title "Supramolecular arrangement of protein in nanoparticle structures predicts nanoparticle tropism for neutrophils in acute lung inflammation"
    .

    https://doi.
    org/10.
    1038/s41565-021-00997-y Researchers studied how neutrophils distinguish between destroyed bacteria and other compounds in the blood (such as cholesterol particles)
    .

    They tested 23 different protein nanoparticles in mice with acute lung injury (ALI), revealing a set of "rules" for predicting neutrophil clearance
    .

    Neutrophils do not remove symmetrical rigid particles (such as viruses), but they remove those "protein aggregation" particles, which researchers call "agglutinated protein nanoparticles (NAP)
    .
    "
    "We hope to use the function of neutrophils to recognize and eliminate invaders and design a'Trojan Horse'->
    .

    "Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening forms of respiratory failure with high morbidity and mortality
    .

    Before the COVID-19 epidemic, there were 190,000 acute respiratory distress syndrome (ARDS) cases and 75,000 deaths in the United States each year.
    Among them, acute respiratory distress syndrome (ARDS) was caused by pneumonia, sepsis, and trauma
    .

    However, COVID-19 has increased the number of acute respiratory distress syndrome (ARDS) cases to millions
    .

    When suffering from acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), the alveoli "mobilize" neutrophils to the lungs to clear the circulating microorganisms
    .

    This process causes the neutrophils to release compounds, further aggravating lung damage and damaging the alveoli, so the patient will have low blood oxygen levels
    .

    Unfortunately, Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrome (ARDS) is very harmful to the human body, but there are no effective drugs to control it.
    The current treatment is mainly to feed the patient and make the lungs naturally slow Healed
    .

    To treat acute respiratory distress syndrome (ARDS) and solve other medical problems, researchers at the University of Pennsylvania and elsewhere have been using nanoparticles to concentrate drugs in injured or diseased organs
    .

    Such nanoparticles are also used in gene therapy and immunotherapy
    .

    The researchers pointed out that we still have a long way to go in the treatment of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) through neutrophils using nanoparticles, but this research represents our understanding of the immune system.
    An important step has been taken in terms of functionality and functionality
    .

    "Now that we have determined that neutrophils will clear the nanoparticles of agglutinated proteins, our next step is to understand how and why other microorganisms, such as viruses, symmetrical rigid microorganisms, evolve to avoid neutrophils," Senior Author Dr.
    Jacob Brenner said, "With this knowledge, we can continue to use this unique combination of materials science and engineering to create disease-specific treatments for more advanced and complex diseases
    .

    " Reference: https://phys .
    org/news/2021-12-blueprint-nanoparticles-white-blood-cells.
    html Note: This article aims to introduce the progress of medical research and cannot be used as a reference for treatment options
    .

    If you need health guidance, please go to a regular hospital for treatment
    .

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