Nature Sub-Journal: Epigenetic changes in the elderly increase the risk of osteoporosis and fractures

As we age, our bones become thinner and thinner, we are more prone to fractures, and bone diseases such as osteoporosis are more likely to occur

For some time now, aging researchers have considered epigenetics as a cause of the aging process

"We want to know why as we age, these stem cells produce less and less substances for bone development and maintenance, resulting in more and more fat accumulating in the bone marrow

Epigenome regeneration

The researchers then investigated whether the epigenome of stem cells can be regenerated

To clarify whether this change in the epigenome may also be the cause of the increased risk of fracture or osteoporosis in the elderly, the researchers studied human bone marrow mesenchymal stem cells from patients after hip surgery

A new way to treat osteoporosis?

"Sodium acetate can also be used as a food additive.

Andromachi Pouikli, Swati Parekh, Monika Maleszewska, Chrysa Nikopoulou, Maarouf Baghdadi, Ignacio Tripodi, Kat Folz-Donahue, Yvonne Hinze, Andrea Mesaros, David Hoey, Patrick Giavalisco, Robin Dowell, Linda Partridge