echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Antitumor Therapy > Nature sub-journal: Fitting bacteria with voice-activated switches for cancer treatment

    Nature sub-journal: Fitting bacteria with voice-activated switches for cancer treatment

    • Last Update: 2022-04-23
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    Chemotherapy has been an important means of cancer treatment since its invention, but the shortcomings of chemotherapy are also very obvious.
    In addition to killing cancer cells, chemotherapy also kills normal cells, such as killing cells in hair follicles, leading to hair loss; Damages the digestive tract
    .

    Chemotherapy has been an important means of cancer treatment since its invention, but the shortcomings of chemotherapy are also very obvious.
    In addition to killing cancer cells, chemotherapy also kills normal cells, such as killing cells in hair follicles, leading to hair loss; Damages the digestive tract
    .
    Digestion

    Recently, Mikhail Shapiro 'steam atthe California Institute of Technologypublished a research paper entitled: Ultrasound-controllable engineered bacteria for cancer immunotherapy in the journal Nature Communications 


    .


    Recently, Mikhail Shapiro 'steam atthe California Institute of Technologypublished a research paper entitled: Ultrasound-controllable engineered bacteria for cancer immunotherapy in the journal Nature Communications 


    The research developed genetically engineered Escherichia coli to express tumor-inhibiting nanobodies and temperature-sensitive gene regulatory switches .


    The research team used the Nissle 1917 E.


    coli strain, which has been approved for human medical use


    The research team used the Nissle 1917 E.


    To turn these bacteria into useful tools for treating cancer, the research team genetically engineered them to contain two additional sets of new genes


    By adding temperature-dependent genes and nanobody genes, the research team created bacterial strains that produced tumor-suppressing nanobodies only when heated to a trigger temperature of 42-43°C


    Since human solid tumors are usually located deep in the body, how can the bacteria at these tumor sites be heated in a targeted manner? The research team used focused ultrasound (FUS) technology, using ultrasound as an energy source to transmit multiple beams of ultrasound from outside the body into the body, focusing on the tumor during the launching process, and converting sound waves and thermal energy to form within 0.


    5-1 second.


    Since human solid tumors are usually located deep in the body, how can the bacteria at these tumor sites be heated in a targeted manner? The research team used focused ultrasound (FUS) technology, using ultrasound as an energy source to transmit multiple beams of ultrasound from outside the body into the body, focusing on the tumor during the launch process, and converting sound waves and thermal energy to form within 0.


    Using focused ultrasound technology, the above-mentioned genetically engineered bacteria can be activated in tumors


    The experimental results showed that tumor mice treated with the engineered bacteria plus ultrasound had slower tumor growth than mice with tumors treated with ultrasound alone, mice treated with the engineered bacteria alone, and mice with tumors that were not treated.


    many


    The experimental results showed that tumor mice treated with the engineered bacteria plus ultrasound had slower tumor growth than mice with tumors treated with ultrasound alone, mice treated with the engineered bacteria alone, and mice with tumors that were not treated.


    According to the research team, this study shows that genetically engineered bacteria + ultrasound therapy is a promising tumor treatment method
    .
    The team will further optimize genetically engineered bacteria and ultrasound to achieve more precise heating stimulation
    .

    According to the research team, this study shows that genetically engineered bacteria + ultrasound therapy is a promising tumor treatment method
    .
    The team will further optimize genetically engineered bacteria and ultrasound to achieve more precise heating stimulation
    .
    precise

    Paper link:

    Paper link:

    https:// Leave a message here

    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.